catalog number :
MBS242318
products full name :
Rabbit Polyclonal to Human VIP
products short name :
VIP
products name syn :
Anti-VIP Antibody (C-Terminus) IHC-plus; VIP; PHM27; Vasoactive intestinal peptide; VIP peptides; Human VIP
other names :
VIP peptides isoform 1 preproprotein; VIP peptides; VIP peptides; prepro-VIP; vasoactive intestinal peptide; Peptide histidine valine 42
other gene names :
VIP; VIP; PHM27; VIP
uniprot entry name :
VIP_HUMAN
purity :
Ammonium sulfate precipitation
form :
PBS, 0.09% sodium azide
storage stability :
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS)
app notes :
Flo (1:10 - 1:50), IHC-P (10 ug/ml), WB (1:1000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: KLH conjugated synthetic peptide selected from the C-terminal region of human VIP.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: VIP antibody was raised against kLH conjugated synthetic peptide selected from the C-terminal region of human VIP. Antigen Modification: C-Terminus
ncbi acc num :
NP_003372.1
ncbi gb acc num :
NM_003381.3
ncbi mol weight :
19,082 Da
ncbi pathways :
G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)
ncbi summary :
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
uniprot summary :
VIP: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6q25. Cellular Component: cell soma; extracellular region. Molecular Function: neuropeptide hormone activity; protein binding; hormone activity. Biological Process: negative regulation of smooth muscle cell proliferation; negative regulation of potassium ion transport; mRNA stabilization; regulation of signal transduction; body fluid secretion; positive regulation of vasodilation; G-protein coupled receptor protein signaling pathway; regulation of protein localization; learning and/or memory; positive regulation of cell proliferation; positive regulation of protein catabolic process; positive regulation of endothelial cell proliferation; regulation of sensory perception of pain; negative regulation of apoptosis