Rabbit Polyclonal (IgG) to Human KLK3 / PSA | MyBioSource MBS242303 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human KLK3 / PSA

catalog :

MBS242303

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS242303

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human KLK3 / PSA

products short name :

KLK3 / PSA

products name syn :

Anti-KLK3 / PSA Antibody IHC-plus; KLK3; APS; Gamma-seminoprotein; Kallikrein-3; Kallikrein-related peptidase 3; P-30 antigen; Prostate specific antigen; Prostate-specific antigen; PSA; Semenogelase; KLK2A1; Seminin; Human KLK3; PSA

other names :

prostate-specific antigen isoform 1 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

products gene name :

KLK3

products gene name syn :

PSA

other gene names :

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS; PSA; Seminin

uniprot entry name :

KLK3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

261

specificity :

Recognizes human Prostate Specific Antigen, Total. No cross-reactivity with human albumin, AFP, CEA, ferritin, hCG, PAP, CA125, CA15-3 or CA19-9.

purity :

Ion exchange Chromatography

form :

PBS, pH 7.4, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA, IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Human prostate specific antigen.

other info2 :

Immunogen Type: Purified protein. Immunogen: KLK3 / PSA antibody was raised against human prostate specific antigen.

products categories :

Family: Protease. Subfamily: Serine S1

products description :

ncbi gi num :

4502173

ncbi acc num :

NP_001639.1

ncbi gb acc num :

NM_001648.2

uniprot acc num :

P07288

ncbi mol weight :

25,116 Da

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Metabolism Of Proteins Pathway (106230); Pathways In Cancer (83105); Prostate Cancer Pathway (755440); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

ncbi summary :

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.77; Protease. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region; nucleus. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis

size1 :

0.05 mg

price1 :

495 USD