antibody

Rabbit Polyclonal to Mouse IL7R / CD127

MBS242247

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Mouse IL7R / CD127

IL7R / CD127

Anti-IL7R / CD127 Antibody (phospho-Tyr449) IHC-plus; IL7R; CD127; CD127 antigen; IL-7RA; IL-7 receptor subunit alpha; IL7RA; ILRA; Interleukin 7 receptor; CDW127; IL-7R subunit alpha; IL-7R-alpha; Mouse IL7R; CD127

interleukin-7 receptor subunit alpha; Interleukin-7 receptor subunit alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; interleukin 7 receptor; CDw127; CD_antigen: CD127

IL7R

CD127

IL7R; IL7R; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA

IL7RA_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

459

A BLAST analysis was used to suggest cross-reactivity with IL-7R from human, mouse and rat sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-7R from other sources has not been determined.

Immunoaffinity Purified

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

1 mg/ml

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:100000), IHC-P (5 ug/ml), WB (1:1000 - 1:10000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Mouse. Immunogen Description: Synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein.

Immunogen Type: Synthetic peptide. Immunogen: IL7R / CD127 antibody was raised against synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein. Antigen Modification: pTyr449

Family: Interleukin

Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation.

28610151

NP_002176.2

NM_002185.3

P16871

28,724 Da

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); FoxO Signaling Pathway (921162); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-7 Signaling Pathway (198857); Immune System Pathway (106386); Interleukin-7 Signaling Pathway (530762); Jak-STAT Signaling Pathway (83077)

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014]

IL7R: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Defects in IL7R are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell- positive/NK-cell-positive (T(-)B(+)NK(+) SCID). A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Genetic variations in IL7R are a cause of susceptibility to multiple sclerosis type 3 (MS3). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major C allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either C allele (Thr-244) or T allele (Ile-244) shows that the C allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated C risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. Belongs to the type I cytokine receptor family. Type 4 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 5p13. Cellular Component: integral to membrane; plasma membrane; extracellular region; external side of plasma membrane. Molecular Function: protein binding; interleukin-7 receptor activity; antigen binding. Biological Process: B cell proliferation; positive regulation of T cell differentiation in the thymus; cell surface receptor linked signal transduction; regulation of DNA recombination; negative regulation of T cell mediated cytotoxicity; cell morphogenesis; homeostasis of number of cells; immune response; immunoglobulin production; cell growth; signal transduction; lymph node development; regulation of cell size; T cell differentiation. Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-positive

0.05 mg

495 USD