Goat Polyclonal to Human ACS5 / ACSL5 | MyBioSource MBS242212 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human ACS5 / ACSL5

catalog :

MBS242212

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242212

products type :

Antibody

products full name :

Goat Polyclonal to Human ACS5 / ACSL5

products short name :

ACS5 / ACSL5

products name syn :

Anti-ACS5 / ACSL5 Antibody (C-Terminus) IHC-plus; ACSL5; ACS2; ACS5; FACL5; Fatty acid coenzyme A ligase 5; Phosphatidylinositol 4-kinase; LACS 5; Human ACS5; ACSL5

other names :

long-chain-fatty-acid--CoA ligase 5 isoform a; Long-chain-fatty-acid--CoA ligase 5; long-chain-fatty-acid--CoA ligase 5; LACS 5; fatty acid coenzyme A ligase 5; long-chain acyl-CoA synthetase 5; FACL5 for fatty acid coenzyme A ligase 5; long-chain fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5; acyl-CoA synthetase long-chain family member 5; Long-chain acyl-CoA synthetase 5; LACS 5

products gene name :

ACS5

products gene name syn :

ACSL5

other gene names :

ACSL5; ACSL5; ACS2; ACS5; FACL5; ACS5; FACL5; LACS 5

uniprot entry name :

ACSL5_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Gorilla, Human, Monkey

sequence length :

739

specificity :

Human ACSL5. This antibody is expected to recognise isoform a (NP_057318.2) and isoform b (NP_976313.1 and NP_976314.1).

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:16000), IHC-P (2.5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-RTQIDSLYEHIQD from the C-terminus of human ACSL5 (NP_057318.2; NP_976313.1; NP_976314.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda (85%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ACS5 / ACSL5 antibody was raised against synthetic peptide C-RTQIDSLYEHIQD from the C-terminus of human ACSL5 (NP_057318.2; NP_976313.1; NP_976314.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda (85%). Antigen Modification: C-Terminus

products categories :

Family: Non-Protein Kinase

ncbi gi num :

42794756

ncbi acc num :

NP_057318.2

ncbi gb acc num :

NM_016234.3

uniprot acc num :

Q9ULC5

ncbi mol weight :

73,278 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid Biosynthesis Pathway (198873); Fatty Acyl-CoA Biosynthesis Pathway (106115); Fatty Acid Biosynthesis Pathway (82933); Fatty Acid Biosynthesis Pathway (294); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296); Fatty Acid Metabolism Pathway (868084)

ncbi summary :

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ACSL5: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 6.2.1.3; Lipid Metabolism - fatty acid; Mitochondrial; Ligase. Chromosomal Location of Human Ortholog: 10q25.2. Cellular Component: mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; nucleolus; integral to membrane; nucleus. Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity. Biological Process: triacylglycerol biosynthetic process; long-chain fatty acid metabolic process; cellular lipid metabolic process

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage