Goat Polyclonal to Human ADAM12 | MyBioSource MBS242207 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human ADAM12

catalog :

MBS242207

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242207

products type :

Antibody

products full name :

Goat Polyclonal to Human ADAM12

products short name :

ADAM12

products name syn :

Anti-ADAM12 Antibody (N-Terminus) IHC-plus; MCMPMltna; MCMP; MLTN; Meltrin-alpha; MLTNA; Human ADAM12

other names :

disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein; Disintegrin and metalloproteinase domain-containing protein 12; disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane; ADAM metallopeptidase domain 12; Meltrin-alpha

products gene name :

ADAM12

other gene names :

ADAM12; ADAM12; MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1; MLTN; ADAM 12

uniprot entry name :

ADA12_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human. Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)

sequence length :

909

specificity :

Human ADAM12. This antibody is expected to recognise both the longer membrane-bound form of human ADAM12 (NP_003465.3) and the shorter soluble ADAM12 splice isoform (NP_067673.2). This antibody does not cross-react with other ADAMS.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:64000), IHC-P (3.75 ug/ml), WB (0.1 - 0.3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide AARPLPVSPARALC from the N-terminus of human ADAM12 (NP_003465.3; NP_067673.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Monkey (85%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ADAM12 antibody was raised against synthetic peptide AARPLPVSPARALC from the N-terminus of human ADAM12 (NP_003465.3; NP_067673.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Monkey (85%). Antigen Modification: N-Terminus

products categories :

Family: Protease. Subfamily: Metallopeptidase M12B

products description :

ADAM12 is a Metallopeptidase M12B type protease.

ncbi gi num :

73747885

ncbi acc num :

NP_003465.3

ncbi gb acc num :

NM_003474.5

uniprot acc num :

O43184

ncbi mol weight :

80,263 Da

ncbi pathways :

Disease Pathway (530764); Notch Signaling Pathway (169345); Signal Transduction Pathway (477114); Signaling By EGFR Pathway (106337); Signaling By EGFR In Cancer Pathway (530768); Signaling By EGFRvIII In Cancer Pathway (1127577); Signaling By Ligand-Responsive EGFR Variants In Cancer Pathway (1127576); Signaling By Overexpressed Wild-Type EGFR In Cancer Pathway (1127579); Syndecan-4-mediated Signaling Events Pathway (138064)

ncbi summary :

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

uniprot summary :

ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis. Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-. Chromosomal Location of Human Ortholog: 10q26. Cellular Component: nucleoplasm; mitochondrion; integral to membrane; plasma membrane; extracellular region. Molecular Function: protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; SH3 domain binding. Biological Process: epidermal growth factor receptor signaling pathway; proteolysis; cell adhesion; myoblast fusion

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage