antibody

Goat Polyclonal to Human AXIN1 / Axin-1

MBS242192

0.05 mg

495 USD

polyclonal

goat

nonconjugated

human, mouse, rat, cow, zebrafish

immunohistochemistry, enzyme immunoassay

Antibody

Goat Polyclonal to Human AXIN1 / Axin-1

AXIN1 / Axin-1

Anti-AXIN1 / Axin-1 Antibody (C-Terminus) IHC-plus; AVPR2; ADHR; AVPR V2; Avp2r; Antidiuretic hormone receptor; DI1; DIR3; NDI; Vasopressin type 2 receptor; Vasopressin type II receptor; Vasopressin V2 receptor; V2 vasopressin receptor; Vasopressin receptor type 2; DIR; Type 2 vasopressin receptor; Human AXIN1; Axin-1

axin-1 isoform a; Axin-1; axin-1; axis inhibitor 1; fused, mouse, homolog of; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49; axin 1; Axis inhibition protein 1; hAxin

AXIN1

AXIN1; AXIN1; AXIN; PPP1R49; AXIN; hAxin

AXIN1_HUMAN

Polyclonal

Goat

Bat, Gibbon, Bovine, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rat, Zebrafish. Predicted Reactivity: Chicken (at least 90% immunogen sequence identity)

862

Human AXIN1. This antibody is expected to recognise both reported isoforms.

Immunoaffinity Purified

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

0.5 mg/ml

Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

ELISA (1:128000), IHC-P (3.75 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic peptide C-FEEKIIGKVEKVD from the C-terminus of human AXIN1 (NP_003493.1; NP_851393.1).

Immunogen Type: Synthetic peptide. Immunogen: AXIN1 / Axin-1 antibody was raised against synthetic peptide C-FEEKIIGKVEKVD from the C-terminus of human AXIN1 (NP_003493.1; NP_851393.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Bat, Horse, Opossum, Stickleback, Pufferfish, Zebrafish (100%); Turkey, Chicken (92%); Xenopus, Sea anemone (85%). Antigen Modification: C-Terminus

27501450

NP_003493.1

NM_003502.3

O15169

91,653 Da

AMER1 Mutants Destabilize The Destruction Complex Pathway 1127621!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1127616!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1127617!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1127620!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1127618!!Basal Cell Carcinoma Pathway 83113!!Basal Cell Carcinoma Pathway 525!!Beta-catenin Phosphorylation Cascade Pathway 106512!!C-MYC Pathway 169344!!Canonical Wnt Signaling Pathway 138032

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

0.05 mg

495 USD