catalog number :
MBS242185
products full name :
Rabbit Polyclonal to Human TNFRSF17 / BCMA
products short name :
TNFRSF17 / BCMA
products name syn :
Anti-TNFRSF17 / BCMA Antibody (C-Terminus) IHC-plus; TNFRSF17; B cell maturation antigen; BCMA; CD269 antigen; B-cell maturation factor; B-cell maturation protein; BCM; CD269; Human TNFRSF17; BCMA
other names :
tumor necrosis factor receptor superfamily member 17; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein; tumor necrosis factor receptor superfamily, member 17; B-cell maturation protein; CD_antigen: CD269
products gene name :
TNFRSF17
products gene name syn :
BCMA
other gene names :
TNFRSF17; TNFRSF17; BCM; BCMA; CD269; TNFRSF13A; BCM; BCMA
uniprot entry name :
TNR17_HUMAN
specificity :
synthetic peptide mapping at the carboxy terminus of human BCMA
purity :
Immunoaffinity Purified
form :
PBS, 0.02% sodium azide.
storage stability :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA, IHC-P (3 ug/ml), WB (2 - 5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human TNFRSF17 / BCMA.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: TNFRSF17 / BCMA antibody was raised against synthetic peptide from human TNFRSF17 / BCMA. Antigen Modification: C-Terminus
products categories :
Family: TNF Receptor
products description :
BCMA is one of three known receptors for BLys/BAFF and APRIL.
ncbi acc num :
NP_001183.2
ncbi gb acc num :
NM_001192.2
ncbi mol weight :
14,843 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670)
ncbi summary :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
uniprot summary :
TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. Protein type: Membrane protein, integral; Receptor, misc.; Oncoprotein. Chromosomal Location of Human Ortholog: 16p13.1. Cellular Component: integral to membrane; plasma membrane; endomembrane system. Molecular Function: receptor activity. Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction