Rabbit Polyclonal (IgG) to Human IL33 | MyBioSource MBS242172 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human IL33

catalog :

MBS242172

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242172

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human IL33

products short name :

IL33

products name syn :

Anti-IL33 Antibody (Internal) IHC-plus; IL33; C9orf26; DVS27; DVS27-related protein; IL-1F11; IL-33; Interleukin-33; NFEHEV; NF-HEV; Interleukin-1 family member 11; NFHEV; IL1F11; Interleukin 33; RP11-575C20.2; Human IL33

other names :

interleukin-33 isoform 1; Interleukin-33; interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; interleukin 33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV

products gene name :

IL33

other gene names :

IL33; IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV

uniprot entry name :

IL33_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

270

specificity :

a 19 amino acid peptide from near the center of human IL-33

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-P (5 ug/ml), WB (1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human IL33 / IL-33.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: IL33 antibody was raised against synthetic peptide from human IL33 / IL-33. Antigen Modification: Internal

products categories :

Family: Interleukin

products description :

Interleukin-33 (IL33) is a cytokine belonging to the IL-1 superfamily. IL33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-kappaB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL5 and IL13) from polarized Th2 cells.

ncbi gi num :

15559209

ncbi acc num :

NP_254274.1

ncbi gb acc num :

NM_033439.3

uniprot acc num :

O95760

ncbi mol weight :

16,250 Da

ncbi pathways :

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Influenza A Pathway (217173); Influenza A Pathway (217150)

ncbi summary :

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

uniprot summary :

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular space; transport vesicle; chromosome; nucleus. Molecular Function: protein binding; cytokine activity. Biological Process: negative regulation of T-helper 1 type immune response; T-helper 2 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage