Goat Polyclonal to Human TPI1 / TPI | MyBioSource MBS242130 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human TPI1 / TPI

catalog :

MBS242130

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow, chimpanzee

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242130

products type :

Antibody

products full name :

Goat Polyclonal to Human TPI1 / TPI

products short name :

TPI1 / TPI

products name syn :

Anti-TPI1 / TPI Antibody (C-Terminus) IHC-plus; TPI1; Triose-phosphate isomerase; Triosephosphate isomerase; TPI; Triosephosphate isomerase 1; TIM; Human TPI1; TPI

other names :

triosephosphate isomerase isoform 1; Triosephosphate isomerase; triosephosphate isomerase; triose-phosphate isomerase; epididymis secretory protein Li 49; triosephosphate isomerase 1; Triose-phosphate isomerase

products gene name :

TPI1

products gene name syn :

TPI

other gene names :

TPI1; TPI1; TIM; TPI; TPID; HEL-S-49; TPI; TIM

uniprot entry name :

TPIS_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Bat, Gibbon, Bovine, Chimpanzee, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat. Predicted Reactivity: Pig, Chicken, Xenopus, Drosophila (at least 90% immunogen sequence identity)

sequence length :

249

specificity :

Human TPI1. This antibody is expected to recognise both reported isoforms.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:16000), IHC-P (5 ug/ml), WB (0.01 - 0.03 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-LKPEFVDIINAKQ from the C-terminus of human TPI1 (NP_000356.1; NP_001152759.1).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: TPI1 / TPI antibody was raised against synthetic peptide C-LKPEFVDIINAKQ from the C-terminus of human TPI1 (NP_000356.1; NP_001152759.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Bovine, Dog, Horse, Rabbit, Salmon, Pike (100%); Pig, Chicken, Xenopus, Smelt, Pufferfish, Drosophila (92%); Catfish, Stickleback, Zebrafish, Neurospora, Beetle, Sordaria, Tick, Chaetomium, Thielavia (85%). Antigen Modification: C-Terminus

ncbi gi num :

4507645

ncbi acc num :

NP_000356.1

ncbi gb acc num :

NM_000365.5

uniprot acc num :

P60174

ncbi mol weight :

17,958 Da

ncbi pathways :

Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Disease Pathway (530764); Fatty Acid Beta Oxidation Pathway (198865); Fructose And Mannose Metabolism Pathway (82930); Fructose And Mannose Metabolism Pathway (291); Gluconeogenesis Pathway (106204); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (413342)

ncbi summary :

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

uniprot summary :

TPI1: Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency). TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. Belongs to the triosephosphate isomerase family. 2 isoforms of the human protein are produced by alternative promoter. Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - inositol phosphate; EC 5.3.1.1; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Isomerase. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: extracellular space; nucleus; cytosol. Molecular Function: protein binding; triose-phosphate isomerase activity. Biological Process: pentose-phosphate shunt; glycolysis; multicellular organismal development; carbohydrate metabolic process; glucose metabolic process; pathogenesis; gluconeogenesis. Disease: Triosephosphate Isomerase Deficiency

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage