catalog number :
MBS242091
products full name :
Rabbit Polyclonal to Human CXCR6
products short name :
CXCR6
products name syn :
Anti-CXCR6 Antibody (N-Terminus) IHC-plus; CXCR6; CD186 antigen; CXCR-6; STRL33; TYMSTR; BONZO; CD186; CDw186; CXC-R6; Human CXCR6
other names :
C-X-C chemokine receptor type 6; C-X-C chemokine receptor type 6; C-X-C chemokine receptor type 6; CDw186; CXC-R6; CXCR-6; G protein-coupled receptor; G-protein coupled receptor bonzo; G-protein coupled receptor STRL33; chemokine (C-X-C motif) receptor 6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD_antigen: CD186
products gene name :
CXCR6
other gene names :
CXCR6; CXCR6; BONZO; CD186; STRL33; TYMSTR; BONZO; STRL33; TYMSTR; CXC-R6; CXCR-6
uniprot entry name :
CXCR6_HUMAN
specificity :
peptide corresponding to amino acids near the amino terminus of human Bonzo/STRL33 The sequence of this peptide differs from those of African green monkey and pig-tailed macaque by one or two amino acids, respectively,
purity :
Immunoaffinity Purified
form :
PBS, 0.02% sodium azide.
concentration :
0.5 mg/ml
storage stability :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
app notes :
IHC-P (2.5 ug/ml), WB (1:500). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human CXCR6.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: CXCR6 antibody was raised against synthetic peptide from human CXCR6. Antigen Modification: N-Terminus
products categories :
Family: GPCR. Subfamily: Chemokine
products description :
Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells.
ncbi acc num :
NP_006555.1
ncbi gb acc num :
NM_006564.1
ncbi mol weight :
39,280 Da
ncbi pathways :
Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)
uniprot summary :
CXCR6: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; coreceptor activity; C-X-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; viral genome replication; inflammatory response; chemotaxis