Goat Polyclonal to Human LCN2 / Lipocalin 2 / NGAL | MyBioSource MBS242074 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human LCN2 / Lipocalin 2 / NGAL

catalog :

MBS242074

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242074

products type :

Antibody

products full name :

Goat Polyclonal to Human LCN2 / Lipocalin 2 / NGAL

products short name :

LCN2 / Lipocalin 2 / NGAL

products name syn :

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (Internal) IHC-plus; LCN2; 24p3; HNL; Lipocalin 2; Lipocalin-2; MSFI; Siderocalin LCN2; NGAL; p25; Lipocalin 2 (oncogene 24p3); Oncogene 24p3; Human LCN2; Lipocalin 2; NGAL

other names :

neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; oncogene 24p3; siderocalin LCN2; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25

products gene name :

LCN2

other gene names :

LCN2; LCN2; 24p3; MSFI; NGAL; HNL; NGAL; NGAL

uniprot entry name :

NGAL_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gorilla, Human

sequence length :

198

specificity :

Human LCN2.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:16000), IHC-P (2.5 ug/ml), WB (1:16000, 0.01 - 0.03 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-AILREDKDPQKMY from an internal region of human LCN2 (NP_005555.2). Percent identity by BLAST analysis: Human, Gorilla (100%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: LCN2 / Lipocalin 2 / NGAL antibody was raised against synthetic peptide C-AILREDKDPQKMY from an internal region of human LCN2 (NP_005555.2). Percent identity by BLAST analysis: Human, Gorilla (100%). Antigen Modification: Internal

ncbi gi num :

38455402

ncbi acc num :

NP_005555.2

ncbi gb acc num :

NM_005564.3

uniprot acc num :

P80188

ncbi mol weight :

22,457 Da

ncbi pathways :

Iron Uptake And Transport Pathway (187191); Orphan Transporters Pathway (1127546); Transmembrane Transport Of Small Molecules Pathway (106572)

uniprot summary :

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: extracellular space; extracellular region; cytosol. Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding. Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage