Goat Polyclonal to Human NR4A1 / NUR77 | MyBioSource MBS242055 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human NR4A1 / NUR77

catalog :

MBS242055

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS242055

products type :

Antibody

products full name :

Goat Polyclonal to Human NR4A1 / NUR77

products short name :

NR4A1 / NUR77

products name syn :

Anti-NR4A1 / NUR77 Antibody (Internal) IHC-plus; NR4A1; GFRP1; Early response protein NAK1; HMR; NGFIB; Orphan nuclear receptor TR3; Orphan receptor tr3; Steroid receptor TR3; TR3; NAK1; NGFI-B; NP10; Receptor NGFIB; Testicular receptor 3; TR3 orphan receptor; N10; NAK-1; NUR77; Human NR4A1; NUR77

other names :

nuclear receptor subfamily 4 group A member 1 isoform 1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4 group A member 1; ST-59; hormone receptor; TR3 orphan receptor; steroid receptor TR3; testicular receptor 3; early response protein NAK1; orphan nuclear receptor HMR; orphan nuclear receptor TR3; nuclear hormone receptor NUR/77; growth factor-inducible nuclear protein N10; nerve growth factor IB nuclear receptor variant 1; nuclear receptor subfamily 4, group A, member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3

products gene name :

NR4A1

products gene name syn :

NUR77

other gene names :

NR4A1; NR4A1; HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77; GFRP1; HMR; NAK1; Nur77

uniprot entry name :

NR4A1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Dog, Gorilla, Hamster, Horse, Human, Mouse, Orangutan, Rabbit, Rat. Predicted Reactivity: Monkey, Bat (at least 90% immunogen sequence identity)

sequence length :

598

specificity :

Human NR4A1 / NUR77. This antibody is expected to recognise isoform a (NP_002126.2 and NP_775180.1) only.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:32000), IHC-P (5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-GRLPSKPKQPPDAS from an internal region of human NR4A1 / NUR77 (NP_002126.2; NP_775180.1).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: NR4A1 / NUR77 antibody was raised against synthetic peptide C-GRLPSKPKQPPDAS from an internal region of human NR4A1 / NUR77 (NP_002126.2; NP_775180.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Dog, Horse, Rabbit (100%); Marmoset, Bat (93%); Bovine (86%). Antigen Modification: Internal

products categories :

Family: NHR. Subfamily: NR4 Nerve growth factor-like

products description :

Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors.

ncbi gi num :

21361342

ncbi acc num :

NP_002126.2

ncbi gb acc num :

NM_002135.4

uniprot acc num :

P22736

ncbi mol weight :

33,754 Da

ncbi pathways :

AKT Phosphorylates Targets In The Nucleus Pathway (106476); Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); Corticotropin-releasing Hormone Pathway (920957); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR Pathway (160957)

ncbi summary :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Nur77: an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5 -AAAAGGTCA-3 . May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Protein type: DNA-binding; Apoptosis; Nuclear receptor. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleus. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity. Biological Process: epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; intracellular receptor-mediated signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; cell migration during sprouting angiogenesis; innate immune response; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation

size1 :

0.05 mg

price1 :

495 USD