catalog number :
MBS242050
products full name :
Goat Polyclonal to Human PIK3CA / PI3K
products short name :
PIK3CA / PI3K
products name syn :
Anti-PIK3CA / PI3K Antibody (Internal) IHC-plus; PIK3CA; MCAP; p110-alpha; p110alpha; PI3K; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3Kalpha; MCM; MCMTC; PI3K-alpha; PtdIns-3-kinase subunit alpha; CLOVE; Human PIK3CA; PI3K
other names :
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3K-alpha; PI3-kinase p110 subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA (EC:2.7.11.1)
products gene name :
PIK3CA
products gene name syn :
PI3K
other gene names :
PIK3CA; PIK3CA; MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; p110-alpha; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha
uniprot entry name :
PK3CA_HUMAN
reactivity :
Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat. Predicted Reactivity: Chicken, Xenopus, Zebrafish (at least 90% immunogen sequence identity)
specificity :
Human PIK3CA.
purity :
Immunoaffinity Purified
form :
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
concentration :
0.5 mg/ml
storage stability :
Store at -20 degree C. Minimize freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
app notes :
ELISA (1:128000), IHC-P (2.5 - 5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide C-HQWLKDKNKGEIYD from an internal region of human PIK3CA (NP_006209.2).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: PIK3CA / PI3K antibody was raised against synthetic peptide C-HQWLKDKNKGEIYD from an internal region of human PIK3CA (NP_006209.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Opossum (100%); Turkey, Chicken, Platypus, Lizard, Xenopus, Stickleback, Pufferfish, Zebrafish (93%). Antigen Modification: Internal
products categories :
Family: Non-Protein Kinase
ncbi acc num :
NP_006209.2
ncbi gb acc num :
NM_006218.2
ncbi mol weight :
124,284 Da
ncbi pathways :
3-phosphoinositide Biosynthesis Pathway 545314!!3-phosphoinositide Biosynthesis Pathway 138600!!AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696
ncbi summary :
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]