Goat Polyclonal to Human SPP1 / Osteopontin | MyBioSource MBS242033 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human SPP1 / Osteopontin

catalog :

MBS242033

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242033

products type :

Antibody

products full name :

Goat Polyclonal to Human SPP1 / Osteopontin

products short name :

SPP1 / Osteopontin

products name syn :

Anti-SPP1 / Osteopontin Antibody (C-Terminus) IHC-plus; SPP1; BSPI; BNSP; Bone sialoprotein 1; ETA-1; Nephropontin; OPN; Secreted phosphoprotein 1; SPP-1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin; Osteopontin; Bone sialoprotein I; Human SPP1; Osteopontin

other names :

osteopontin isoform OPN-b; Osteopontin; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein 1; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin

products gene name :

SPP1

other gene names :

SPP1; SPP1; OPN; BNSP; BSPI; ETA-1; BNSP; OPN; SPP-1

uniprot entry name :

OSTP_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Gorilla, Human, Orangutan. Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)

sequence length :

300

specificity :

Human SPP1 / Osteopontin.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:64000), IHC-P (5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-DPKSKEEDKHLK from the C-terminus of human SPP1 / Osteopontin (NP_001035147.1; NP_000573.1; NP_001035149.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset (92%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: SPP1 / Osteopontin antibody was raised against synthetic peptide C-DPKSKEEDKHLK from the C-terminus of human SPP1 / Osteopontin (NP_001035147.1; NP_000573.1; NP_001035149.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset (92%); Mouse, Panda, Dog, Pig, Arthrobotrys (83%). Antigen Modification: C-Terminus

products description :

Osteopontin (OPN) is an integrin-binding protein overexpressed in various experimental models of malignancy and appears to be involved in tumorigenesis and metastasis.

ncbi gi num :

4759166

ncbi acc num :

NP_000573.1

ncbi gb acc num :

NM_000582.2

uniprot acc num :

P10451

ncbi mol weight :

33,843 Da

ncbi pathways :

BDNF Signaling Pathway (712093); Degradation Of The Extracellular Matrix Pathway (576263); Direct P53 Effectors Pathway (137939); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); FGF Signaling Pathway (137989); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067)

ncbi summary :

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

osteopontin: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q22.1. Cellular Component: extracellular space; cell projection; perinuclear region of cytoplasm; apical part of cell; extracellular region. Molecular Function: protein binding; extracellular matrix binding; cytokine activity. Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; decidualization; osteoblast differentiation; extracellular matrix disassembly; response to vitamin D; biomineral formation; response to steroid hormone stimulus; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; cell adhesion; inflammatory response; embryo implantation

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage