Rabbit Polyclonal to Human TNFSF15 / TL1A / VEGI | MyBioSource MBS242030 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human TNFSF15 / TL1A / VEGI

catalog :

MBS242030

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS242030

products type :

Antibody

products full name :

Rabbit Polyclonal to Human TNFSF15 / TL1A / VEGI

products short name :

TNFSF15 / TL1A / VEGI

products name syn :

Anti-TNFSF15 / TL1A / VEGI Antibody (N-Terminus) IHC-plus; TNFSF15; TL1; TL1A; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; VEGI192A; VEGI; Human TNFSF15; TL1A; VEGI

other names :

tumor necrosis factor ligand superfamily member 15 isoform VEGI-251; Tumor necrosis factor ligand superfamily member 15; tumor necrosis factor ligand superfamily member 15; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A; tumor necrosis factor (ligand) superfamily, member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitorCleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form

products gene name :

TNFSF15

products gene name syn :

TL1A; VEGI

other gene names :

TNFSF15; TNFSF15; TL1; TL1A; VEGI; VEGI192A; TL1; VEGI

uniprot entry name :

TNF15_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

251

specificity :

Peptide corresponding to 14 amino acids near the N-terminus of human TL1A, specific to isoform 1 of O95150, also known as VEGI-251.

purity :

Ion exchange Chromatography

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human TNFSF15 / TL1A.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: TNFSF15 / TL1A / VEGI antibody was raised against synthetic peptide from human TNFSF15 / TL1A. Antigen Modification: N-Terminus

products categories :

Family: TNF

products description :

TNF Superfamily Ligand TL1A (TL1A, TNFSF15) is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).

ncbi gi num :

23510445

ncbi acc num :

NP_005109.2

ncbi gb acc num :

NM_005118.3

uniprot acc num :

O95150

ncbi mol weight :

20,131 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Senescence And Autophagy Pathway (198780)

ncbi summary :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

uniprot summary :

TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine; Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 9q32. Cellular Component: extracellular space; integral to plasma membrane; integral to membrane; plasma membrane. Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: caspase activation; cytokine metabolic process; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion

size1 :

0.05 mg

price1 :

495 USD