Goat Polyclonal to Human TREM2 / TREM-2 | MyBioSource MBS242024 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human TREM2 / TREM-2

catalog :

MBS242024

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS242024

products type :

Antibody

products full name :

Goat Polyclonal to Human TREM2 / TREM-2

products short name :

TREM2 / TREM-2

products name syn :

Anti-TREM2 / TREM-2 Antibody (C-Terminus) IHC-plus; TREM2; Trem2b; TREM-2; Trem2a; Trem2c; Human TREM2; TREM-2

other names :

triggering receptor expressed on myeloid cells 2 isoform 1; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2

products gene name :

TREM2

products gene name syn :

TREM-2

other gene names :

TREM2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2

uniprot entry name :

TREM2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human. Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)

sequence length :

230

specificity :

Human TREM2.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA (1:32000), IHC-P (2.5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-HGQKPGTHPPSELD from the C-terminus of human TREM2 (NP_061838.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (93%), Gibbon (93%), Monkey (93%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: TREM2 / TREM-2 antibody was raised against synthetic peptide C-HGQKPGTHPPSELD from the C-terminus of human TREM2 (NP_061838.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (93%), Gibbon (93%), Monkey (93%). Antigen Modification: C-Terminus

ncbi gi num :

9507203

ncbi acc num :

NP_061838.1

ncbi gb acc num :

NM_018965.3

uniprot acc num :

Q9NZC2

ncbi mol weight :

24,669 Da

ncbi pathways :

Axon Guidance Pathway (105688); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Developmental Biology Pathway (477129); Immune System Pathway (106386); Innate Immune System Pathway (106387); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Other Semaphorin Interactions Pathway (119526); Semaphorin Interactions Pathway (119519)

ncbi summary :

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

uniprot summary :

TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: intracellular membrane-bound organelle; extracellular region; plasma membrane; integral to membrane. Molecular Function: peptidoglycan binding; lipopolysaccharide binding; receptor activity. Biological Process: axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; positive regulation of calcium-mediated signaling; humoral immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II. Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage