antibody

Goat Polyclonal to Human KDM2B / FBXL10

MBS241985

0.05 mg

495 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, chicken, cow

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Goat Polyclonal to Human KDM2B / FBXL10

KDM2B / FBXL10

Anti-KDM2B / FBXL10 Antibody (C-Terminus) IHC-plus; KDM2B; CXXC2; Fbl10; F-box/LRR-repeat protein 10; JHDM1B; F-box protein FBL10; FBXL10; Lysine-specific demethylase 2B; PCCX2; Protein JEMMA; Human KDM2B; FBXL10

lysine-specific demethylase 2B isoform b; Lysine-specific demethylase 2B; lysine-specific demethylase 2B; F-box protein FBL10; F-box/LRR-repeat protein 10; CXXC-type zinc finger protein 2; protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B; F-box and leucine-rich repeat protein 10; jumonji C domain-containing histone demethylase 1B; jmjC domain-containing histone demethylation protein 1B; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; lysine (K)-specific demethylase 2B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B

KDM2B

FBXL10

KDM2B; KDM2B; CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Protein JEMMA

KDM2B_HUMAN

Polyclonal

Goat

Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat

1265

Human KDM2B / FBXL10. This antibody is expected to recognize isoform a (NP_115979.3) only.

Immunoaffinity Purified

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

0.5 mg/ml

Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

ELISA (1:32000), IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic peptide C-FGQVEEKLLQKLS from the C-terminus of human KDM2B / FBXL10 (NP_115979.3).

Immunogen Type: Synthetic peptide. Immunogen: KDM2B / FBXL10 antibody was raised against synthetic peptide C-FGQVEEKLLQKLS from the C-terminus of human KDM2B / FBXL10 (NP_115979.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Turkey, Chicken, Platypus (100%); Xenopus (85%). Antigen Modification: C-Terminus

Family: F-Box

54112380

NP_001005366.1

NM_001005366.1

Q8NHM5

144,769 Da

Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); HDMs Demethylate Histones Pathway (1127685)

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

FBXL10: Histone demethylase that demethylates Lys-4 and Lys- 36 of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 and dimethylated H3 Lys-36 residue while it has weak or no activity for mono- and tri-methylated H3 Lys-36 . Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.14.11.27; Oxidoreductase; Nucleolus; Demethylase; DNA-binding. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: nucleoplasm; nucleolus; PcG protein complex; nucleus. Molecular Function: rRNA binding; protein binding; histone demethylase activity; DNA binding; zinc ion binding; histone demethylase activity (H3-K36 specific). Biological Process: midbrain-hindbrain boundary morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; fourth ventricle development; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; midbrain development; forebrain development; spermatogenesis; embryonic camera-type eye morphogenesis; negative regulation of neuron apoptosis; lateral ventricle development; hindbrain development

0.05 mg

495 USD