This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Goat Polyclonal to Human DCTN1 / Dynactin 1
catalog :
MBS241945
quantity :
0.05 mg
price :
495 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, dog, cow
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
product information
catalog number :
MBS241945
products type :
Antibody
products full name :
Goat Polyclonal to Human DCTN1 / Dynactin 1
products short name :
DCTN1 / Dynactin 1
products name syn :
Anti-DCTN1 / Dynactin 1 Antibody (C-Terminus) IHC-plus; DCTN1; DAP-150; Dynactin subunit 1; DP-150; Dynactin 1; HMN7B; p150-glued; p135; Human DCTN1; Dynactin 1
other names :
dynactin subunit 1 isoform 2; Dynactin subunit 1; dynactin subunit 1; 150 kDa dynein-associated polypeptide; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued
products gene name :
DCTN1
other gene names :
DCTN1; DCTN1; P135; DP-150; DAP-150; DP-150
uniprot entry name :
DCTN1_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan. Predicted Reactivity: Rat, Bovine, Dog, Pig, Rabbit (at least 90% immunogen sequence identity)
sequence length :
1144
specificity :
Human DCTN1. This antibody is expected to recognise all reported isoforms (NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1).
purity :
Immunoaffinity Purified
form :
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
concentration :
0.5 mg/ml
storage stability :
Store at -20 degree C. Minimize freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA (1:128000), IHC-P (2.5 ug/ml), WB (1:128000, 0.5 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide C-QEQLHQLHSRLIS from the C-terminus of human DCTN1 (NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Hamster, Horse (100%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: DCTN1 / Dynactin 1 antibody was raised against synthetic peptide C-QEQLHQLHSRLIS from the C-terminus of human DCTN1 (NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Hamster, Horse (100%); Rat, Bovine, Dog, Panda, Rabbit, Pig (92%); Bat (85%). Antigen Modification: C-Terminus
products description :
Mutations in dynactin 1 have been implicated in an inherited motor neuron disease.
ncbi gi num :
13259508
ncbi acc num :
NP_075408.1
ncbi gb acc num :
NM_023019.3
uniprot acc num :
Q14203
ncbi mol weight :
140,887 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Anchoring Of The Basal Body To The Plasma Membrane Pathway 1127503!!Assembly Of The Primary Cilium Pathway 1127502!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Centrosome Maturation Pathway 105807!!G2/M Transition Pathway 105801!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!IRE1alpha Activates Chaperones Pathway 105906
ncbi summary :
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
size :
0.05 mg
price :
495 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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