catalog number :
MBS241920
products full name :
Rabbit Polyclonal (IgG) to Human VEGFA / VEGF
products short name :
VEGFA / VEGF
products name syn :
Anti-VEGFA / VEGF Antibody IHC-plus; VEGFA; VPF; Vascular permeability factor; VEGF; VEGF-A; MVCD1; Human VEGFA; VEGF
other names :
vascular endothelial growth factor A isoform b; Vascular endothelial growth factor A; vascular endothelial growth factor A; vascular permeability factor; vascular endothelial growth factor A; Vascular permeability factor; VPF
products gene name :
VEGFA
products gene name syn :
VEGF
other gene names :
VEGFA; VEGFA; VPF; VEGF; MVCD1; VEGF; VEGF-A; VPF
uniprot entry name :
VEGFA_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Recognizes human Vascular Endothelial Growth Factor (VEGF).
purity :
Protein A Purified
form :
PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide
storage stability :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin)
app notes :
IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Human recombinant VEGF165. Cellular Localization: Cytoplasmic, cell surface and extracellular matrix. MW: 19-22kD (reduced).
other info2 :
Immunogen Type: Recombinant protein. Immunogen: VEGFA / VEGF antibody was raised against human recombinant VEGF165. Cellular Localization: Cytoplasmic, cell surface and extracellular matrix. MW: 19-22kD (reduced).
products categories :
Family: PDGF
products description :
VEGFA was originally isolated as a heparin-binding secreted factor from bovine pituitary folliculo-stellate cells. It is a direct acting mitogen specific for vascular endothelial cells and capable of stimulating angiogenesis in vivo. In addition to inducing endothelial cell proliferation it promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Molecular cloning has revealed multiple forms of VEGFA arising from alternative splicing of the RNA transcript.
ncbi acc num :
NP_003367.4
ncbi gb acc num :
NM_003376.5
ncbi mol weight :
34,406 Da
ncbi pathways :
Angiogenesis Pathway 198772!!Axon Guidance Pathway 105688!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cellular Response To Hypoxia Pathway 645259!!Cellular Responses To Stress Pathway 645258!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 477129!!EPH-Ephrin Signaling Pathway 1127691
ncbi summary :
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]