Goat Polyclonal to Human GFAP | MyBioSource MBS241916 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human GFAP

catalog :

MBS241916

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat, dog, chicken, cow

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241916

products type :

Antibody

products full name :

Goat Polyclonal to Human GFAP

products short name :

GFAP

products name syn :

Anti-GFAP Antibody (C-Terminus) IHC-plus; GFAP; Human GFAP

other names :

glial fibrillary acidic protein isoform 1; Glial fibrillary acidic protein; glial fibrillary acidic protein; glial fibrillary acidic protein

products gene name :

GFAP

other gene names :

GFAP; GFAP; GFAP

uniprot entry name :

GFAP_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Monkey, Rat, Bat, Bovine, Horse, Rabbit. Predicted Reactivity: Mouse, Dog, Pig, Chicken

sequence length :

432

specificity :

Human GFAP.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:32000), IHC-P (5 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: MBS241916 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS241916 was determined to be 5 ug/ml.

other info1 :

Target: GFAP. Target Species: Human. Immunogen Description: Synthetic peptide C-DGEVIKESKQEHKD from the C-terminus of human GFAP (NP_002046.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset, Rat, Bat, Bovine, Elephant, Horse, Rabbit (100%). Antigen Type: Synthetic peptide

other info2 :

Immunogen: GFAP antibody was raised against synthetic peptide C-DGEVIKESKQEHKD from the C-terminus of human GFAP (NP_002046.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset, Rat, Bat, Bovine, Elephant, Horse, Rabbit (100%); Mouse, Dog, Pig, Turkey, Chicken (93%); Opossum, Lizard (86%). Antigen Modification: C-Terminus

products description :

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

ncbi gi num :

4503979

ncbi acc num :

NP_002046.1

ncbi gb acc num :

NM_002055.4

uniprot acc num :

P14136

ncbi pathways :

Neural Crest Differentiation Pathway (672460); Nuclear Signaling By ERBB4 Pathway (530744); Signal Transduction Pathway (477114); Signaling By ERBB4 Pathway (530741); Spinal Cord Injury Pathway (739007)

ncbi summary :

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

uniprot summary :

GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21. Cellular Component: membrane; cytoplasm; intermediate filament; cytosol. Molecular Function: integrin binding; structural constituent of cytoskeleton; kinase binding. Biological Process: Bergmann glial cell differentiation; extracellular matrix organization and biogenesis; regulation of neurotransmitter uptake; response to wounding; intermediate filament organization; neurite regeneration; astrocyte development. Disease: Alexander Disease

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage