Rabbit Polyclonal (IgG) to Human SMAD6 | MyBioSource MBS241862 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human SMAD6

catalog :

MBS241862

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog

application :

western blot, immunohistochemistry

product information

catalog number :

MBS241862

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human SMAD6

products short name :

SMAD6

products name syn :

Anti-SMAD6 Antibody (aa85-99) IHC-plus; SMAD6; AOVD2; HSMAD6; HsT17432; SMAD 6; MADH7; Mothers against DPP homolog 6; SMAD family member 6; MAD homolog 6; MADH6; Human SMAD6

other names :

mothers against decapentaplegic homolog 6; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic homolog 6; MAD homolog 6; SMAD, mothers against DPP homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD family member 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6

products gene name :

SMAD6

other gene names :

SMAD6; SMAD6; AOVD2; MADH6; MADH7; HsT17432; MADH6; MAD homolog 6; Mothers against DPP homolog 6; SMAD 6; Smad6; hSMAD6

uniprot entry name :

SMAD6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Pig. Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)

sequence length :

496

specificity :

Synthetic peptides corresponding to amino acids 85-99 (RAGGPPRPMSEPGAG) and amino acids 372-388 (NLEQRSESVRRTRSKIG) of human SMAD6 (GenBank Accession No. AAH12986.1). These peptide sequences are specific to SMAD6, and have high homology to SMAD6in multiple species.

purity :

Protein G Purified

form :

PBS, 0.05% BSA, 0.05% sodium azide.

concentration :

0.5 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: This antibody was developed against synthetic peptides corresponding to amino acids 85-99 (RAGGPPRPMSEPGAG)and amino acids 372-388 (NLEQRSESVRRTRSKIG)of human SMAD6 (GenBank Accession No. AAH12986.1).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: SMAD6 antibody was raised against this antibody was developed against synthetic peptides corresponding to amino acids 85-99 (RAGGPPRPMSEPGAG)and amino acids 372-388 (NLEQRSESVRRTRSKIG)of human SMAD6 (GenBank Accession No. AAH12986.1). These peptide sequences are specific to SMAD6, and have high homology to SMAD6in multiple species. Percent identity by BLAST analysis: Human, Pig (100%); Dog, Bovine, Opossum (93%); Gibbon, Marmoset, Rat (87%); Elephant (80%). Antigen Modification: aa85-99

ncbi gi num :

92859871

ncbi acc num :

NP_005576.3

ncbi gb acc num :

NM_005585.4

uniprot acc num :

O43541

ncbi mol weight :

35,467 Da

ncbi pathways :

BMP Receptor Signaling Pathway (137948); BMP Signalling And Regulation Pathway (198910); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Integrated Breast Cancer Pathway (219801); Integrated Pancreatic Cancer Pathway (711360); Signal Transduction Pathway (477114); Signaling By BMP Pathway (106336); TGF Beta Signaling Pathway (198810); TGF-beta Receptor Signaling Pathway (198774)

ncbi summary :

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]

uniprot summary :

SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 15q22.31. Cellular Component: transcription factor complex; protein complex; cytoplasm; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; metal ion binding; ubiquitin protein ligase binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; chromatin binding; transcription factor activity. Biological Process: fat cell differentiation; BMP signaling pathway; negative regulation of cell proliferation; zygotic determination of dorsal/ventral axis; transcription, DNA-dependent; response to estrogen stimulus; ureteric bud development; transforming growth factor beta receptor signaling pathway; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell-substrate adhesion; negative regulation of BMP signaling pathway; negative regulation of apoptosis. Disease: Aortic Valve Disease 2

size1 :

0.05 mg

price1 :

495 USD