Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2 / SAPK | MyBioSource MBS241853 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2 / SAPK

catalog :

MBS241853

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, immunohistochemistry

product information

catalog number :

MBS241853

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2 / SAPK

products short name :

MAPK9 / JNK2 / SAPK

products name syn :

Anti-MAPK9 / JNK2 / SAPK Antibody (aa373-389) IHC-plus; MAPK9; C-Jun kinase 2; C-Jun N-terminal kinase 2; JNK2B; JNK2; JNK2ALPHA; MAP kinase 9; p54a; JNK2BETA; PRKM9; SAPK; MAPK 9; p54aSAPK; SAPK1a; JNK-55; JNK2A; Jun kinase; Human MAPK9; JNK2; SAPK

other names :

mitogen-activated protein kinase 9 isoform alpha2; Mitogen-activated protein kinase 9; mitogen-activated protein kinase 9; MAPK 9; Jun kinase; MAP kinase 9; c-Jun kinase 2; c-Jun N-terminal kinase 2; stress-activated protein kinase 1a; stress-activated protein kinase JNK2; mitogen-activated protein kinase 9; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2

products gene name :

MAPK9

products gene name syn :

JNK2; SAPK

other gene names :

MAPK9; MAPK9; JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA; JNK2; PRKM9; SAPK1A; MAP kinase 9; MAPK 9; SAPK1a

uniprot entry name :

MK09_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Bat, Gibbon, Bovine, Gorilla, Human, Pig, Rabbit. Predicted Reactivity: Monkey, Mouse, Rat, Hamster, Horse (at least 90% immunogen sequence identity)

sequence length :

424

specificity :

A synthetic peptide corresponding to amino acids 373-389 (KDQPSDAAVSSNATPSQ) of human JNK2 was used as immunogen. This amino acid sequence is 100% homologous in cow and dog, and 94% in mouse and rat.

purity :

Protein G Purified

form :

PBS, 0.2% gelatin, 0.05% sodium azide.

concentration :

0.5 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (10 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: A synthetic peptide corresponding to amino acids 373-389 (KDQPSDAAVSSNATPSQ) of human JNK2 was used as immunogen; GenBank no. gi 21237736 ref NP_002743.3 . This amino sequence is 100% homologous in cow and dog, and 94% in mouse and rat.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MAPK9 / JNK2 / SAPK antibody was raised against a synthetic peptide corresponding to amino acids 373-389 (KDQPSDAAVSSNATPSQ) of human JNK2 was used as immunogen; GenBank no. gi 21237736 ref NP_002743.3 . This amino sequence is 100% homologous in cow and dog, and 94% in mouse and rat. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Elephant, Bat, Bovine, Rabbit, Pig (100%); Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Horse (94%); Platypus (82%). Antigen Modification: aa373-389

products categories :

Family: Protein Kinase. Subfamily: MAPK

products description :

JNK2, a MAPK type protein kinase, regulates cell apoptosis, differentiation and growth in response to growth factors, inflammatory cytokines and cellular stress. JNK2 is phosphorylated by by MKK4/MAP2K4 and MKK7/MAP2K7. Activated JNK2 translocates to the nucleus where it phosphorylates transcription factors, including c-Jun, ATF2, ELK1, Jun-D and NFAT4.

ncbi gi num :

21237736

ncbi acc num :

NP_002743.3

ncbi gb acc num :

NM_002752.4

uniprot acc num :

P45984

ncbi mol weight :

27,334 Da

ncbi pathways :

AGE/RAGE Pathway 698754!!ATF-2 Transcription Factor Network Pathway 138006!!Activated TLR4 Signalling Pathway 106400!!Activation Of The AP-1 Family Of Transcription Factors Pathway 160139!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!BDNF Signaling Pathway 712093!!CD40/CD40L Signaling Pathway 138061!!CDC42 Signaling Events Pathway 137994!!Cellular Senescence Pathway 905991

ncbi summary :

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

size :

0.05 mg

price :

495 USD