Rabbit Polyclonal to Human ALK2 / ACVR1 | MyBioSource MBS241817 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human ALK2 / ACVR1

catalog :

MBS241817

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241817

products type :

Antibody

products full name :

Rabbit Polyclonal to Human ALK2 / ACVR1

products short name :

ALK2 / ACVR1

products name syn :

Anti-ALK2 / ACVR1 Antibody (aa496-509) IHC-plus; ACVR1; Activin A receptor type I; Activin A receptor; type I; ACTR-I; ActRIA; ACVR1A; ALK2; Activin receptor-like kinase 2; Activin receptor type-1; ACTRI; ACVRLK2; ALK-2; Activin receptor type I; Actr1; FOP; Hydroxyalkyl-protein kinase; SKR1; TSRI; Human ALK2; ACVR1

other names :

activin receptor type-1; Activin receptor type-1; activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; activin A receptor, type I; Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I

products gene name :

ALK2

products gene name syn :

ACVR1

other gene names :

ACVR1; ACVR1; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I

uniprot entry name :

ACVR1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Xenopus. Predicted Reactivity: Chicken

sequence length :

509

specificity :

A portion of amino acids 475-509 of human ACVR1 was used as the immunogen.

purity :

Protein G Purified

form :

PBS, 0.2% gelatin, 0.05% sodium azide.

concentration :

0.5 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (10 ug/ml), WB (3 - 5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS241817 was determined to be 10 ug/ml

other info1 :

Target: ALK2/ACVR1. Target Species: Human. Immunogen Description: A synthetic peptide corresponding to amino acids 496-509 (TKIDNSLDKLKTDC) of amino acids 475-525 of human ACVR1 was used as immunogen, GenBank NP 001096. Antigen Type: Synthetic peptide

other info2 :

Immunogen Species: ALK2/ ACVR1 antibody was raised against Human. Immunogen: ALK2 / ACVR1 antibody was raised against a synthetic peptide corresponding to amino acids 496-509 (TKIDNSLDKLKTDC) of amino acids 475-525 of human ACVR1 was used as immunogen, GenBank NP 001096. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Xenopus (100%); Opossum, Turkey, Chicken, Platypus, Salmon (93%); Stickleback, Pufferfish (86%). Antigen Modification: aa496-509

products categories :

Family: Protein Kinase. Subfamily: Activin/TGFb

ncbi gi num :

4501895

ncbi acc num :

NP_001096.1

ncbi gb acc num :

NM_001105.4

uniprot acc num :

Q04771

ncbi pathways :

ALK1 Pathway (137985); ALK1 Signaling Events Pathway (137968); ALK2 Signaling Events Pathway (137983); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); TGF-beta Signaling Pathway (83064)

ncbi summary :

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

uniprot summary :

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily. Chromosomal Location of Human Ortholog: 2q23-q24. Cellular Component: apical part of cell; integral to plasma membrane; activin receptor complex. Molecular Function: protein homodimerization activity; peptide hormone binding; metal ion binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity. Biological Process: positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; positive regulation of osteoblast differentiation; negative regulation of activin receptor signaling pathway; mesoderm formation; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle development; regulation of ossification; determination of left/right symmetry; urogenital system development; acute inflammatory response; G1/S transition of mitotic cell cycle. Disease: Fibrodysplasia Ossificans Progressiva

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage