antibody

Rabbit Polyclonal to Human ACHE / Acetylcholinesterase

MBS241710

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal to Human ACHE / Acetylcholinesterase

ACHE / Acetylcholinesterase

Anti-ACHE / Acetylcholinesterase Antibody (N-Terminus) IHC-plus; ACHE; ACEE; Acetylcholinesterase; N-ACHE; Yt blood group; ARACHE; YT; Human ACHE; Acetylcholinesterase

acetylcholinesterase isoform E4-E5; Acetylcholinesterase; acetylcholinesterase; Yt blood group; apoptosis-related acetylcholinesterase; acetylcholinesterase (Yt blood group)

ACHE

ACHE; ACHE; YT; ACEE; ARACHE; N-ACHE; AChE

ACES_HUMAN

Polyclonal

Rabbit

Human

617

synthetic peptide corresponding to N-terminal residues of human ACHE (N-terminal extended acetylcholinesterase)

Immunoaffinity Purified

PBS, 0.01% sodium azide, 50% glycerol.

0.5 mg/ml

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (20 ug/ml), WB (1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic peptide from human ACHE / Acetylcholinesterase.

Immunogen Type: Synthetic peptide. Immunogen: ACHE / Acetylcholinesterase antibody was raised against synthetic peptide from human ACHE / Acetylcholinesterase. Antigen Modification: N-Terminus

Acetylcholinesterase is involved in termination of signal transmission at neuromuscular junctions. Differences in assembly and localization of the multiple synaptic forms of acetylcholinesterase are thought to arise through posttranscriptional events. The Yt erythrocyte blood group antigen system resides on the acetylcholinesterase molecule.

7710112

NP_056646.1

NM_015831.2

P22303

58,352 Da

ATF-2 Transcription Factor Network Pathway (138006); Acetylcholine Synthesis Pathway (198820); Biogenic Amine Synthesis Pathway (198793); Cholinergic Synapse Pathway (217716); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Integrated Pancreatic Cancer Pathway (711360); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

ACHE: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor; Hydrolase; EC 3.1.1.7; Lipid Metabolism - glycerophospholipid. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region; synapse; basal lamina; cell junction; nucleus; neuromuscular junction. Molecular Function: collagen binding; protein binding; serine hydrolase activity; protein homodimerization activity; protein self-association; cholinesterase activity; hydrolase activity; beta-amyloid binding; laminin binding; acetylcholinesterase activity; acetylcholine binding. Biological Process: negative regulation of synaptic transmission, cholinergic; nervous system development; muscle development; acetylcholine catabolic process in synaptic cleft; acetylcholine catabolic process; glycerophospholipid biosynthetic process; osteoblast development; synaptic transmission; cell proliferation; synaptogenesis; positive regulation of protein secretion; retina development in camera-type eye; amyloid precursor protein metabolic process; neurotransmitter receptor biosynthetic process; phospholipid metabolic process; receptor internalization; phosphatidylcholine biosynthetic process; response to wounding; regulation of receptor recycling; DNA replication; cell adhesion; protein tetramerization; neurotransmitter biosynthetic process. Disease: Yt Blood Group Antigen

0.05 mg

495 USD