Rabbit Polyclonal to Human GRK5 | MyBioSource MBS241704 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human GRK5

catalog :

MBS241704

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, cow

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241704

products type :

Antibody

products full name :

Rabbit Polyclonal to Human GRK5

products short name :

GRK5

products name syn :

Anti-GRK5 Antibody IHC-plus; GRK5; FP2025; GPRK5; Human GRK5

other names :

G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 5; FP2025; g protein-coupled receptor kinase GRK5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5

products gene name :

GRK5

other gene names :

GRK5; GRK5; GPRK5; GPRK5

uniprot entry name :

GRK5_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Bovine, Chicken, Human, Mouse, Pufferfish, Rat, Zebrafish

sequence length :

590

specificity :

A portion of amino acid 350-400 of human GRK5

purity :

Immunoaffinity Purified

form :

PBS, 0.2% gelatin, 0.05% sodium azide.

concentration :

0.5 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (20 ug/ml), WB (0.5 - 4 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human GRK5.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: GRK5 antibody was raised against synthetic peptide from human GRK5.

products categories :

Family: Protein Kinase. Subfamily: GPRK

ncbi gi num :

4885349

ncbi acc num :

NP_005299.1

ncbi gb acc num :

NM_005308.2

uniprot acc num :

P34947

ncbi mol weight :

67,787 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913); Calcium Regulation In The Cardiac Cell Pathway (198906); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Endocytosis Pathway (102279); Endocytosis Pathway (102181); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Morphine Addiction Pathway (552665)

ncbi summary :

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

uniprot summary :

GRK5: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70- interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2- mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G- protein-coupled receptor, LRP6 during Wnt signaling (in vitro). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Protein type: Kinase, protein; EC 2.7.11.16; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; GRK subfamily. Chromosomal Location of Human Ortholog: 10q26.11. Cellular Component: nucleoplasm; nuclear membrane; focal adhesion; cytoplasm; plasma membrane; nucleus. Molecular Function: protein serine/threonine kinase activity; G-protein coupled receptor kinase activity; protein binding; protein kinase C binding; phospholipid binding; ATP binding. Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; tachykinin signaling pathway; Wnt receptor signaling pathway; apoptosis; protein amino acid autophosphorylation; regulation of G-protein coupled receptor protein signaling pathway; negative regulation of apoptosis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage