Rabbit Polyclonal to Human RAB7A / RAB7 | MyBioSource MBS241680 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human RAB7A / RAB7

catalog :

MBS241680

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat, dog, chicken, cow, chimpanzee, zebrafish

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241680

products type :

Antibody

products full name :

Rabbit Polyclonal to Human RAB7A / RAB7

products short name :

RAB7A / RAB7

products name syn :

Anti-RAB7A / RAB7 Antibody (aa90-140) IHC-plus; RAB7A; CMT2B; PRO2706; RAB7; Ras-associated protein RAB7; Ras-related protein Rab-7a; PSN; Human RAB7A; RAB7

other names :

ras-related protein Rab-7a; Ras-related protein Rab-7a; ras-related protein Rab-7a; Ras-associated protein RAB7; RAB7, member RAS oncogene family; RAB7A, member RAS oncogene family

products gene name :

RAB7A

products gene name syn :

RAB7

other gene names :

RAB7A; RAB7A; RAB7; PRO2706; RAB7

uniprot entry name :

RAB7A_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Bovine, Chimpanzee, Chicken, Dog, Xenopus, Human, Monkey, Rat, Zebrafish

sequence length :

207

specificity :

A portion of amino acids 90-140 of human Rab7 protein

purity :

Immunoaffinity Purified

form :

PBS, 0.05% BSA, 0.05% sodium azide.

concentration :

0.5 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (10 ug/ml), WB (0.5 - 1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human RAB7A / RAB7.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: RAB7A / RAB7 antibody was raised against synthetic peptide from human RAB7A / RAB7. Antigen Modification: aa90-140

products description :

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7A encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori.

ncbi gi num :

34147513

ncbi acc num :

NP_004628.4

ncbi gb acc num :

NM_004637.5

uniprot acc num :

P51149

ncbi mol weight :

23,490 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Endocytosis Pathway (102279); Endocytosis Pathway (102181); IL12-mediated Signaling Events Pathway (137922); Immune System Pathway (106386); MHC Class II Antigen Presentation Pathway (645290); Phagosome Pathway (153910); Phagosome Pathway (153859)

ncbi summary :

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

uniprot summary :

Rab7: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab. Chromosomal Location of Human Ortholog: 3q21.3. Cellular Component: Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; lysosomal membrane; retromer complex; lysosome; late endosome; pre-autophagosomal structure membrane; vacuolar membrane; melanosome; phagocytic vesicle. Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding. Biological Process: protein transport; protein targeting to lysosome; early endosome to late endosome transport; endosome to lysosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein to membrane docking; endocytosis; Rab protein signal transduction; retrograde transport, endosome to Golgi; epidermal growth factor ligand processing; bone resorption. Disease: Charcot-marie-tooth Disease, Axonal, Type 2b

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage