Goat Polyclonal to Human HRH1 / Histamine H1 Receptor | MyBioSource MBS241639 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human HRH1 / Histamine H1 Receptor

catalog :

MBS241639

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow, chimpanzee

application :

immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS241639

products type :

Antibody

products full name :

Goat Polyclonal to Human HRH1 / Histamine H1 Receptor

products short name :

HRH1 / Histamine H1 Receptor

products name syn :

Anti-HRH1 / Histamine H1 Receptor Antibody (C-Terminus) IHC-plus; HRH1; H1 histamine receptor; H1 receptor; Histamine 1 receptor; Histamine H1 receptor; H1-R; H1R; Histamine H(1) receptor; Histamine receptor H1; HisH1; Human HRH1; Histamine H1 Receptor

other names :

histamine H1 receptor; Histamine H1 receptor; histamine H1 receptor; histamine receptor, subclass H1; histamine receptor H1

products gene name :

HRH1

other gene names :

HRH1; HRH1; H1R; H1-R; HH1R; hisH1; H1R; HH1R

uniprot entry name :

HRH1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Bat, Gibbon, Chimpanzee, Gorilla, Human, Orangutan. Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken (at least 90% immunogen sequence identity)

sequence length :

487

specificity :

Human HRH1 / Histamine H1 Receptor. Variants (NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1) encode the same protein.

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA (1:32000), IHC-P (2.5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide CNENFKKTFKRILH from the C-terminus of human HRH1 / Histamine H1 Receptor (NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: HRH1 / Histamine H1 Receptor antibody was raised against synthetic peptide CNENFKKTFKRILH from the C-terminus of human HRH1 / Histamine H1 Receptor (NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Bat, Platypus (100%); Monkey, Mouse, Rat, Dog, Bovine, Hamster, Elephant, Panda, Rabbit, Horse, Pig, Turkey, Chicken (93%); Marmoset, Guinea pig, Xenopus (86%). Antigen Modification: C-Terminus

products categories :

Family: GPCR. Subfamily: Histamine

products description :

The H1 Histamine Receptor (HRH1) has been implicated in the inflammatory cascade and allergic response. It is expressed by some inflammatory cells and by vascular smooth muscle as well as smooth muscle of other organs. Activation of HRH1 expressed in the central nervous system has been shown to regulate the release of neurotransmitters and hormones. H1 receptors modulate a variety of physiological functions including arousal, anxiety, nociception, learning, and food and water intake.

ncbi gi num :

4504491

ncbi acc num :

NP_000852.1

ncbi gb acc num :

NM_000861.3

uniprot acc num :

P35367

ncbi mol weight :

55,784 Da

ncbi pathways :

Amine Ligand-binding Receptors Pathway 106363!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class A Rhodopsin-like Pathway 198886

ncbi summary :

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

size :

0.05 mg

price :

495 USD