Rabbit Polyclonal (IgG) to Human MCAD / ACADM | MyBioSource MBS241600 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human MCAD / ACADM

catalog :

MBS241600

quantity :

0.1 mL

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241600

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human MCAD / ACADM

products short name :

MCAD / ACADM

products name syn :

Anti-MCAD / ACADM Antibody IHC-plus; ACADM; ACAD1; MCAD; MCADH; Human MCAD; ACADM

other names :

medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; acyl-CoA dehydrogenase, C-4 to C-12 straight chain

products gene name :

MCAD

products gene name syn :

ACADM

other gene names :

ACADM; ACADM; MCAD; ACAD1; MCADH; MCAD

uniprot entry name :

ACADM_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Pig, Sheep

sequence length :

421

specificity :

Human recombinant MCAD1

purity :

Protein A Purified

form :

Tris buffered saline, 0.1% BSA, 0.02% sodium azide.

concentration :

0.6 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (10 ug/ml), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Recombinant human ACADM.

other info2 :

Immunogen Type: Recombinant protein. Immunogen: MCAD / ACADM antibody was raised against recombinant human ACADM.

products description :

ACADM encodes the medium-chain specific (C4 to C12 straight chain) Acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Clinical phenotypes are associated with ACADM hereditary deficiency.

ncbi gi num :

4557231

ncbi acc num :

NP_000007.1

ncbi gb acc num :

NM_000016.5

uniprot acc num :

P11310

ncbi mol weight :

47,020 Da

ncbi pathways :

Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway (106127); Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway (106128); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296); Fatty Acid Metabolism Pathway (868084); Fatty Acid Metabolism Pathway (878045)

ncbi summary :

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Oxidoreductase; Other Amino Acids Metabolism - beta-alanine; Lipid Metabolism - fatty acid; Mitochondrial; EC 1.3.8.7. Chromosomal Location of Human Ortholog: 1p31. Cellular Component: mitochondrion; axon; mitochondrial matrix; nucleus. Molecular Function: acyl-CoA dehydrogenase activity; identical protein binding; FAD binding. Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process. Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of

size1 :

0.1 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage