Goat Polyclonal to Rabbit PKM / Pyruvate Kinase | MyBioSource MBS241592 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Rabbit PKM / Pyruvate Kinase

catalog :

MBS241592

quantity :

0.05 mL

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241592

products type :

Antibody

products full name :

Goat Polyclonal to Rabbit PKM / Pyruvate Kinase

products short name :

PKM / Pyruvate Kinase

products name syn :

Anti-PKM / Pyruvate Kinase Antibody IHC-plus; PKM; p58; PK3; PKM2; Pyruvate Kinase; Pyruvate kinase 2/3; Pyruvate kinase; m1; Pyruvate kinase; muscle; TCB; Tumor M2-PK; OIP-3; OIP3; Opa-interacting protein 3; CTHBP; PK; muscle type; PK2; Pyruvate kinase isozymes M1/M2; Rabbit PKM; Pyruvate Kinase

other names :

pyruvate kinase PKM isoform a; Pyruvate kinase PKM; pyruvate kinase PKM; p58; OIP-3; tumor M2-PK; PK, muscle type; pyruvate kinase 2/3; OPA-interacting protein 3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; thyroid hormone-binding protein 1; epididymis secretory protein Li 30; cytosolic thyroid hormone-binding protein; thyroid hormone-binding protein, cytosolic; pyruvate kinase, muscle; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58

products gene name :

PKM

other gene names :

PKM; PKM; PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; OIP3; PK2; PK3; PKM2; CTHBP; OIP-3; THBP1

uniprot entry name :

KPYM_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Rabbit

sequence length :

531

specificity :

Pyruvate Kinase (Rabbit Muscle).

purity :

Purified IgG

form :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide

concentration :

10 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

app notes :

ELISA (1:4000 - 1:20000), IHC-P (5 ug/ml), IP, WB (1:500 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Rabbit. Immunogen Description: Pyruvate kinase purified from rabbit muscle.

other info2 :

Immunogen: PKM / Pyruvate Kinase antibody was raised against pyruvate kinase purified from rabbit muscle.

products description :

ncbi gi num :

33286418

ncbi acc num :

NP_002645.3

ncbi gb acc num :

NM_002654.4

uniprot acc num :

P14618

ncbi mol weight :

56,273 Da

ncbi pathways :

Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway (618580); Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway (468242); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Disease Pathway (530764); Glucose Metabolism Pathway (106199)

ncbi summary :

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

uniprot summary :

PKM2: one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. Overexpressed in a variety of cancers. Interacts with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. Binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogens is. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms of PKM2 have been reported. Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Nucleotide Metabolism - purine; EC 2.7.1.40; Carbohydrate Metabolism - pyruvate; Mitochondrial; Kinase, other. Chromosomal Location of Human Ortholog: 15q22. Cellular Component: extracellular matrix; mitochondrion; cytoplasm; plasma membrane; cytosol; nucleus; vesicle; cilium. Molecular Function: potassium ion binding; protein binding; magnesium ion binding; pyruvate kinase activity; ATP binding. Biological Process: glycolysis; carbohydrate metabolic process; programmed cell death; glucose metabolic process; pathogenesis; phosphorylation

size1 :

0.05 mL

price1 :

495 USD

more info or order :

MyBioSource product webpage