Rabbit Polyclonal to Human MAPK3 / ERK1 | MyBioSource MBS241505 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human MAPK3 / ERK1

catalog :

MBS241505

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS241505

products type :

Antibody

products full name :

Rabbit Polyclonal to Human MAPK3 / ERK1

products short name :

MAPK3 / ERK1

products name syn :

Anti-MAPK3 / ERK1 Antibody (Internal) IHC-plus; MAPK3; ERK-1; ERT2; HUMKER1A; HS44KDAP; MAP kinase 1; MAP kinase isoform p44; MAPK 1; MAPK 3; p44; p44MAPK; p44-MAPK; p44ERK1; Insulin-stimulated MAP2 kinase; MAP kinase 3; p44-ERK1; ERK1; PRKM3; Human MAPK3; ERK1

other names :

mitogen-activated protein kinase 3 isoform 2; Mitogen-activated protein kinase 3; mitogen-activated protein kinase 3; MAPK 1; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1

products gene name :

MAPK3

products gene name syn :

ERK1

other gene names :

MAPK3; MAPK3; ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK

uniprot entry name :

MK03_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Gorilla, Human, Monkey. Predicted Reactivity: Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)

sequence length :

357

specificity :

Human MAPK3 / ERK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MAPK1 (70%).

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (4 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 20 amino acid peptide from internal region of human MAPK3 / ERK1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bovine, Hamster, Elephant, Panda, Horse, Pig (95%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MAPK3 / ERK1 antibody was raised against synthetic 20 amino acid peptide from internal region of human MAPK3 / ERK1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bovine, Hamster, Elephant, Panda, Horse, Pig (95%); Dog, Rabbit, Opossum, Platypus (90%); Bat (85%). Antigen Modification: Internal

products categories :

Family: Protein Kinase. Subfamily: MAPK

products description :

ERK1, a MAPK -type protein kinase, is a member of the Ras-MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins, and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK1 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK1 causing dissociation of the MEK/ERK complex.

ncbi gi num :

91718897

ncbi acc num :

NP_001035145.1

ncbi gb acc num :

NM_001040056.2

uniprot acc num :

P27361

ncbi mol weight :

40,088 Da

ncbi pathways :

AGE/RAGE Pathway 698754!!ALK1 Signaling Events Pathway 137968!!ARMS-mediated Activation Pathway 106466!!ATF-2 Transcription Factor Network Pathway 138006!!Activated TLR4 Signalling Pathway 106400!!Activation Of The AP-1 Family Of Transcription Factors Pathway 160139!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481

ncbi summary :

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

size :

0.05 mg

price :

495 USD