Rabbit Polyclonal to Human ADAMTS1 | MyBioSource MBS241501 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human ADAMTS1

catalog :

MBS241501

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241501

products type :

Antibody

products full name :

Rabbit Polyclonal to Human ADAMTS1

products short name :

ADAMTS1

products name syn :

Anti-ADAMTS1 Antibody (Internal) IHC-plus; ADAM-TS; ADAMTS-1; ADAM-TS 1; C3-C5; ADAM-TS1; METH-1; METH1; KIAA1346; Human ADAMTS1

other names :

A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; METH-1

products gene name :

ADAMTS1

other gene names :

ADAMTS1; ADAMTS1; C3-C5; METH1; KIAA1346; METH1; ADAM-TS 1; ADAM-TS1; ADAMTS-1

uniprot entry name :

ATS1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Gorilla, Human, Monkey, Orangutan. Predicted Reactivity: Horse (at least 90% immunogen sequence identity)

sequence length :

967

specificity :

Human ADAMTS1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from internal region of human ADAMTS1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Elephant, Horse (94%); Bat, Pig (88%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ADAMTS1 antibody was raised against synthetic 17 amino acid peptide from internal region of human ADAMTS1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Elephant, Horse (94%); Bat, Pig (88%); Mouse, Rat, Hamster, Rabbit (82%). Antigen Modification: Internal

products categories :

Family: Protease. Subfamily: Metallopeptidase M12B

products description :

ADAMTS1 is a Metallopeptidase M12B type protease.

ncbi gi num :

50845384

ncbi acc num :

NP_008919.3

ncbi gb acc num :

NM_006988.4

uniprot acc num :

Q9UHI8

ncbi mol weight :

105,358 Da

ncbi pathways :

Degradation Of The Extracellular Matrix Pathway (576263); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Metabolism Of Proteins Pathway (106230); O-glycosylation Of TSR Domain-containing Proteins Pathway (1127680); O-linked Glycosylation Pathway (1127679); Post-translational Protein Modification Pathway (161012)

ncbi summary :

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

uniprot summary :

ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. Protein type: EC 3.4.24.-; Secreted; Motility/polarity/chemotaxis; Protease; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 21q21.2. Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle. Molecular Function: heparin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity. Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; proteolysis; kidney development; ovulation from ovarian follicle

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage