Rabbit Polyclonal to Human ADAMTS4 | MyBioSource MBS241496 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human ADAMTS4

catalog :

MBS241496

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241496

products type :

Antibody

products full name :

Rabbit Polyclonal to Human ADAMTS4

products short name :

ADAMTS4

products name syn :

Anti-ADAMTS4 Antibody (C-Terminus) IHC-plus; ADAMTS4; ADAMTS-2; ADAMTS-4; ADAM-TS 4; ADAM-TS4; ADMP-1; Aggrecanase-1; KIAA0688; Human ADAMTS4

other names :

A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; Aggrecanase-1

products gene name :

ADAMTS4

other gene names :

ADAMTS4; ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4

uniprot entry name :

ATS4_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Dog, Horse, Human, Orangutan. Predicted Reactivity: Monkey, Bat, Bovine (at least 90% immunogen sequence identity)

sequence length :

837

specificity :

Human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from C-terminus of human ADAMTS4. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Dog, Horse (100%); Marmoset, Bat, Bovine, Elephant, Panda (94%); Monkey, Pig, Opossum (88%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ADAMTS4 antibody was raised against synthetic 17 amino acid peptide from C-terminus of human ADAMTS4. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Dog, Horse (100%); Marmoset, Bat, Bovine, Elephant, Panda (94%); Monkey, Pig, Opossum (88%); Mouse, Rat, Hamster (82%). Antigen Modification: C-Terminus

products categories :

Family: Protease. Subfamily: Metallopeptidase M12B

products description :

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif.

ncbi gi num :

157427675

ncbi acc num :

NP_005090.3

ncbi gb acc num :

NM_005099.4

uniprot acc num :

O75173

ncbi mol weight :

83,030 Da

ncbi pathways :

Degradation Of The Extracellular Matrix Pathway (576263); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Metabolism Of Proteins Pathway (106230); O-glycosylation Of TSR Domain-containing Proteins Pathway (1127680); O-linked Glycosylation Pathway (1127679); Post-translational Protein Modification Pathway (161012)

ncbi summary :

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

uniprot summary :

ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site. Protein type: Secreted; EC 3.4.24.82; Protease; Secreted, signal peptide; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q21-q23. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region. Molecular Function: peptidase activity; protein binding; protease binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity. Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage