Rabbit Polyclonal (IgG) to Human Tuberin / TSC2 | MyBioSource MBS241471 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal (IgG) to Human Tuberin / TSC2

catalog :

MBS241471

quantity :

0.05 mL

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

product information

catalog number :

MBS241471

products type :

Antibody

products full name :

Rabbit Polyclonal (IgG) to Human Tuberin / TSC2

products short name :

Tuberin / TSC2

products name syn :

Anti-Tuberin / TSC2 Antibody (phospho-Ser664) IHC-plus; TSC2; LAM; Tuberous sclerosis 2 protein; TSC4; Tuberin; Tuberous sclerosis 2; Human Tuberin; TSC2

other names :

tuberin isoform 1; Tuberin; tuberin; tuberous sclerosis 2 protein; protein phosphatase 1, regulatory subunit 160; tuberous sclerosis 2; Tuberous sclerosis 2 protein

products gene name :

TSC2

other gene names :

TSC2; TSC2; LAM; TSC4; PPP1R160; TSC4

uniprot entry name :

TSC2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

1807

specificity :

Modified peptide

purity :

Affinity Purified

form :

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.

concentration :

0.35 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF)

app notes :

IF, IHC-P (1:50). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human TSC2.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: Tuberin / TSC2 antibody was raised against synthetic peptide from human TSC2. Antigen Modification: pSer664

products description :

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors.

ncbi gi num :

116256352

ncbi acc num :

NP_000539.2

ncbi gb acc num :

NM_000548.3

uniprot acc num :

P49815

ncbi mol weight :

25,773 Da

ncbi pathways :

AKT Phosphorylates Targets In The Cytosol Pathway (106475); AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adaptive Immune System Pathway (366160); BDNF Signaling Pathway (712093); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549)

ncbi summary :

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described. Protein type: GAPs; Cell cycle regulation; Tumor suppressor; GAPs, misc.; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: TSC1-TSC2 complex; Golgi apparatus; cytoskeleton; growth cone; cell soma; membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; caveola; nucleus; cytosol. Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding. Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; negative regulation of Wnt receptor signaling pathway; regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; protein heterooligomerization; regulation of cell cycle; heart development; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; negative regulation of cell proliferation; protein localization; cell projection organization and biogenesis; positive chemotaxis; protein import into nucleus; regulation of endocytosis; acute-phase response; protein kinase B signaling cascade; cell cycle arrest; protein homooligomerization; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; negative regulation of TOR signaling pathway; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; fibroblast growth factor receptor signaling pathway; endocytosis; vesicle-mediated transport; insulin-like growth factor receptor signaling pathway; glucose import; neural tube closure; insulin receptor signaling pathway; response to hypoxia; innate immune response; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of phosphoinositide 3-kinase cascade. Disease: Lymphangioleiomyomatosis; Tuberous Sclerosis 2

size1 :

0.05 mL

price1 :

495 USD