This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Polyclonal to Human CRFR1 / CRHR1
catalog :
MBS241427
quantity :
0.05 mg
price :
495 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, cow
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
catalog number :
MBS241427
products type :
Antibody
products full name :
Rabbit Polyclonal to Human CRFR1 / CRHR1
products short name :
CRFR1 / CRHR1
products name syn :
Anti-CRFR1 / CRHR1 Antibody (N-Terminus) IHC-plus; CRHR1; CRF-R-1; CRFR; CRHR1f; Crf receptor 1; CRH-R1; CRF-R; CRF1; CRFR-1; Crf receptor type 1; Crf receptor type 1; Crf type 1; CRF-R1; Crf1 receptor; CRFR1; CRH-R-1; CRH-R1h; CRHR; CRHR1L; Human CRFR1; CRHR1
other names :
corticotropin-releasing factor receptor 1 isoform 1; Corticotropin-releasing factor receptor 1; corticotropin-releasing factor receptor 1; CRH receptor 1; seven transmembrane helix receptor; corticotropin-releasing factor type 1 receptor; corticotropin releasing hormone receptor 1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
products gene name :
CRFR1
products gene name syn :
CRHR1
other gene names :
CRHR1; CRHR1; CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1; CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1
uniprot entry name :
CRFR1_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Gibbon, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rat. Predicted Reactivity: Bat, Bovine, Pig (at least 90% immunogen sequence identity)
sequence length :
444
specificity :
Human CRF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CRHR2 (73%).
purity :
Immunoaffinity Purified
form :
PBS, 0.1% sodium azide.
concentration :
1 mg/ml
storage stability :
Long term: -70 degree C; Short term: +4 degree C
tested application :
Immunohistochemistry (IHC - Paraffin)
app notes :
IHC-P (15 - 20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic 15 amino acid peptide from N-terminal extracellular domain of human CRF1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Hamster, Panda, Horse (100%); Bat, Bovine, Pig.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: CRFR1 / CRHR1 antibody was raised against synthetic 15 amino acid peptide from N-terminal extracellular domain of human CRF1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Hamster, Panda, Horse (100%); Bat, Bovine, Pig, Opossum (93%); Elephant (87%); Sheep, Lizard (80%). Antigen Modification: N-Terminus
products categories :
Family: GPCR. Subfamily: Corticotropin releasing factor
products description :
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing.
ncbi gi num :
223717971
ncbi acc num :
NP_001138618.1
ncbi gb acc num :
NM_001145146.1
uniprot acc num :
P34998
ncbi mol weight :
28,122 Da
ncbi pathways :
Class B/2 (Secretin Family Receptors) Pathway (106378); Corticotropin-releasing Hormone Pathway (920957); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class B Secretin-like Pathway (198781); Long-term Depression Pathway (83086); Long-term Depression Pathway (497)
ncbi summary :
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]
uniprot summary :
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described. Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 17q21.31. Cellular Component: multivesicular body; cell soma; integral to plasma membrane; apical part of cell; dendrite; plasma membrane; integral to membrane; trans-Golgi network; vesicle; intrinsic to plasma membrane. Molecular Function: protein binding; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity. Biological Process: fear response; hypothalamus development; hormone-mediated signaling; adrenal gland development; adenylate cyclase activation; positive regulation of mast cell degranulation; behavioral response to ethanol; female pregnancy; memory; general adaptation syndrome, behavioral process; elevation of cytosolic calcium ion concentration; behavioral response to pain; epithelial cell differentiation; neuropeptide signaling pathway; adrenocorticotropin hormone secretion; behavioral response to cocaine; response to hypoxia; negative regulation of epinephrine secretion; visual learning; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; parturition; response to electrical stimulus
size1 :
0.05 mg
price1 :
495 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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