catalog number :
MBS241401
products full name :
Rabbit Polyclonal (IgG) to Mouse RB1 / Retinoblastoma / RB
products short name :
RB1 / Retinoblastoma / RB
products name syn :
Anti-RB1 / Retinoblastoma / RB Antibody (N-Terminus) IHC-plus; RB1; p105-Rb; Osteosarcoma; PRb; Retinoblastoma; Retinoblastoma 1; OSRC; RB; Pp110; Mouse RB1; Retinoblastoma; RB
other names :
retinoblastoma-associated protein; Retinoblastoma-associated protein; retinoblastoma-associated protein; retinoblastoma suspectibility protein; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; retinoblastoma 1; p105-Rb; pRb; Rb; pp110
other gene names :
RB1; RB1; RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; Rb
uniprot entry name :
RB_HUMAN
reactivity :
Human, Mouse
specificity :
Recombinant (partial), N-terminal
purity :
Immunoaffinity Purified
form :
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
concentration :
0.5 mg/ml
storage stability :
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)
app notes :
IF, IHC-P (1:100), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Mouse. Immunogen Description: Recombinant mouse RB1.
other info2 :
Immunogen Type: Recombinant protein. Immunogen: RB1 / Retinoblastoma / RB antibody was raised against recombinant mouse RB1. Antigen Modification: N-Terminus
ncbi acc num :
NP_000312.2
ncbi gb acc num :
NM_000321.2
ncbi mol weight :
106,159 Da
ncbi pathways :
Adipogenesis Pathway 198832!!Androgen Receptor Signaling Pathway 198806!!B Cell Receptor Signaling Pathway 198909!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463
ncbi summary :
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]