catalog number :
MBS241368
products full name :
Rabbit Polyclonal to Mouse Leptin
products short name :
Leptin
products name syn :
Anti-Leptin Antibody IHC-plus; Leptin; LEPD; Obese protein; Obese; mouse; homolog of; Obesity factor; OBS; OB; Mouse Leptin
other names :
leptin; Leptin; leptin; obese protein; obesity factor; obese, mouse, homolog of; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin; Obese protein; Obesity factor
other gene names :
LEP; LEP; OB; OBS; LEPD; OB; OBS
uniprot entry name :
LEP_HUMAN
reactivity :
Human, Mouse
specificity :
Recombinant mouse leptin 16000 MW produced in E Coli.
purity :
Unpurified serum
form :
Contains 0.01% sodium azide
storage stability :
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
app notes :
ELISA, IHC-P (5 ug/ml), WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Mouse. Immunogen Description: Recombinant mouse LEP / Leptin.
other info2 :
Immunogen Type: Recombinant protein. Immunogen: Leptin antibody was raised against recombinant mouse LEP / Leptin.
products description :
Leptin has been implicated in the control of appetite and metabolism.
ncbi acc num :
NP_000221.1
ncbi gb acc num :
NM_000230.2
ncbi mol weight :
18,641 Da
ncbi pathways :
AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Adipogenesis Pathway 198832!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 477129!!HIF-1-alpha Transcription Factor Network Pathway 138045
ncbi summary :
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]