Rabbit Polyclonal to Human TNFSF11 / RANKL / TRANCE | MyBioSource MBS241339 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human TNFSF11 / RANKL / TRANCE

catalog :

MBS241339

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

catalog number :

MBS241339

products type :

Antibody

products full name :

Rabbit Polyclonal to Human TNFSF11 / RANKL / TRANCE

products short name :

TNFSF11 / RANKL / TRANCE

products name syn :

Anti-TNFSF11 / RANKL / TRANCE Antibody (Internal) IHC-plus; TNFSF11; CD254; CD254 antigen; HRANKL2; OPTB2; TRANCE; ODF; OPGL; SOdf; Osteoprotegerin ligand; RANKL; Human TNFSF11; RANKL; TRANCE

other names :

tumor necrosis factor ligand superfamily member 11 isoform 1; Tumor necrosis factor ligand superfamily member 11; tumor necrosis factor ligand superfamily member 11; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor (ligand) superfamily, member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form

products gene name :

TNFSF11

products gene name syn :

RANKL; TRANCE

other gene names :

TNFSF11; TNFSF11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE

uniprot entry name :

TNF11_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

317

specificity :

14 amino acid peptide from near the center of human sRANK-L

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (5 ug/ml), WB (0.25 - 0.5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human TNFSF11 / RANKL.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: TNFSF11 / RANKL / TRANCE antibody was raised against synthetic peptide from human TNFSF11 / RANKL. Antigen Modification: Internal

products categories :

Family: TNF

products description :

OPG ligand (OPGL,) a type II membrane protein, binds to a unique hematopoietic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes involved in osteoclast development. OPGL is expressed in the primitive mesenchymal cells, in hypertrophying chondrocytes and in areas undergoing primary ossification and modeling. This gene was independently isolated and called RANKL (receptor activator of NF-Kappa B ligand).

ncbi gi num :

4507595

ncbi acc num :

NP_003692.1

ncbi gb acc num :

NM_003701.3

uniprot acc num :

O14788

ncbi mol weight :

30,523 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!IL6-mediated Signaling Events Pathway 137932!!NF-kappa B Signaling Pathway 634527!!Osteoblast Signaling Pathway 198842!!Osteoclast Signaling Pathway 198769!!Osteoclast Differentiation Pathway 193147!!Osteoclast Differentiation Pathway 193096!!Prolactin Signaling Pathway 814182!!Prolactin Signaling Pathway 814248

ncbi summary :

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

size :

0.05 mg

price :

495 USD