Rabbit Polyclonal to Human PDCD1 / CD279 / PD-1 | MyBioSource MBS241303 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human PDCD1 / CD279 / PD-1

catalog :

MBS241303

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241303

products type :

Antibody

products full name :

Rabbit Polyclonal to Human PDCD1 / CD279 / PD-1

products short name :

PDCD1 / CD279 / PD-1

products name syn :

Anti-PDCD1 / CD279 / PD-1 Antibody (Internal) IHC-plus; PDCD1; CD279; HPD-1; HPD-l; PD1; Protein PD-1; SLEB2; PD-1; CD279 antigen; Programmed cell death 1; Human PDCD1; CD279; PD-1

other names :

programmed cell death protein 1; Programmed cell death protein 1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2; programmed cell death 1; CD_antigen: CD279

products gene name :

PDCD1

products gene name syn :

CD279; PD-1

other gene names :

PDCD1; PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; PD1; Protein PD-1; hPD-1

uniprot entry name :

PDCD1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

288

specificity :

16 amino acid peptide from near the center of human PDCD1.

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (10 ug/ml), WB (1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human PDCD1 / CD279.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: PDCD1 / CD279 / PD-1 antibody was raised against synthetic peptide from human PDCD1 / CD279. Antigen Modification: Internal

products categories :

Family: Apoptosis

products description :

PD-1 (PDCD1) encodes a cell surface membrane protein of the immunoglobulin superfamily. PD-1 is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for PD-1 bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.

ncbi gi num :

167857792

ncbi acc num :

NP_005009.2

ncbi gb acc num :

NM_005018.2

uniprot acc num :

Q15116

ncbi mol weight :

31,647 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); PD-1 Signaling Pathway (119557); T Cell Receptor Signaling Pathway (83080); T Cell Receptor Signaling Pathway (491)

ncbi summary :

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

uniprot summary :

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse exhausted T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells. Protein type: Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: signal transducer activity; protein binding. Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response. Disease: Systemic Lupus Erythematosus

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage