Rabbit Polyclonal to Human NPHS1 / Nephrin | MyBioSource MBS241298 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human NPHS1 / Nephrin

catalog :

MBS241298

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241298

products type :

Antibody

products full name :

Rabbit Polyclonal to Human NPHS1 / Nephrin

products short name :

NPHS1 / Nephrin

products name syn :

Anti-NPHS1 / Nephrin Antibody (C-Terminus) IHC-plus; NPHS1; Nephrin; NPHN; CNF; Human NPHS1; Nephrin

other names :

nephrin; Nephrin; nephrin; renal glomerulus-specific cell adhesion receptor; nephrosis 1, congenital, Finnish type (nephrin); Renal glomerulus-specific cell adhesion receptor

products gene name :

NPHS1

other gene names :

NPHS1; NPHS1; CNF; NPHN; nephrin; NPHN

uniprot entry name :

NPHN_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1241

specificity :

14 amino acid peptide from near the carboxy terminus of human Nephrin.

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (5 ug/ml), WB (1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human NPHS1 / Nephrin.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: NPHS1 / Nephrin antibody was raised against synthetic peptide from human NPHS1 / Nephrin. Antigen Modification: C-Terminus

products categories :

Family: Immunoglobulin

ncbi gi num :

4758822

ncbi acc num :

NP_004637.1

ncbi gb acc num :

NM_004646.3

uniprot acc num :

O60500

ncbi mol weight :

130,546 Da

ncbi pathways :

Cell-Cell Communication Pathway (477132); Nephrin Interactions Pathway (187228); Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway (138072)

ncbi summary :

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]

uniprot summary :

NPHS1: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1. Interacts with NPHS2. Specifically expressed in podocytes of kidney glomeruli. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: cell projection; protein complex; integral to plasma membrane; plasma membrane; lipid raft. Molecular Function: protein domain specific binding; protein binding; spectrin binding; myosin binding; alpha-actinin binding. Biological Process: skeletal muscle development; positive regulation of actin filament polymerization; glomerular basement membrane development; JNK cascade; cell adhesion; excretion; myoblast fusion. Disease: Nephrotic Syndrome, Type 1

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage