Rabbit Polyclonal to Human IRS1 / IRS-1 | MyBioSource MBS241289 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human IRS1 / IRS-1

catalog :

MBS241289

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241289

products type :

Antibody

products full name :

Rabbit Polyclonal to Human IRS1 / IRS-1

products short name :

IRS1 / IRS-1

products name syn :

Anti-IRS1 / IRS-1 Antibody (Internal) IHC-plus; IRS1; IRS-1; HIRS-1; Insulin receptor substrate 1; Human IRS1; IRS-1

other names :

insulin receptor substrate 1; Insulin receptor substrate 1; insulin receptor substrate 1; IRS-1; insulin receptor substrate 1

products gene name :

IRS1

products gene name syn :

IRS-1

other gene names :

IRS1; IRS1; HIRS-1; IRS-1

uniprot entry name :

IRS1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1242

specificity :

16 amino acid peptide from near the center of human IRS-1

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)

app notes :

ICC, IHC-P (5 ug/ml), WB (1 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human IRS1.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: IRS1 / IRS-1 antibody was raised against synthetic peptide from human IRS1. Antigen Modification: Internal

ncbi gi num :

5031805

ncbi acc num :

NP_005535.1

ncbi gb acc num :

NM_005544.2

uniprot acc num :

P35568

ncbi mol weight :

131,591 Da

ncbi pathways :

AGE/RAGE Pathway (698754); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adaptive Immune System Pathway (366160); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Alpha6-Beta4 Integrin Signaling Pathway (198807)

ncbi summary :

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

uniprot summary :

IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 2q36. Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; nucleus; cytosol. Molecular Function: insulin-like growth factor receptor binding; protein binding; signal transducer activity; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; signal transduction; glucose homeostasis; negative regulation of insulin secretion; response to insulin stimulus; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; mammary gland development; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; regulation of gene expression; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; protein kinase B signaling cascade; insulin receptor signaling pathway; innate immune response; positive regulation of insulin receptor signaling pathway; lipid catabolic process; positive regulation of cell migration. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage