catalog number :
MBS241270
products full name :
Rabbit Polyclonal to Human MTOR
products short name :
MTOR
products name syn :
Anti-MTOR Antibody (N-Terminus) IHC-plus; MTOR; FRAP1; FRAP2; FRAP; Mammalian target of rapamycin; RAFT1; Rapamycin and FKBP12 target 1; RAPT1; Rapamycin target protein 1; Human MTOR
other names :
serine/threonine-protein kinase mTOR; Serine/threonine-protein kinase mTOR; serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; mechanistic target of rapamycin (serine/threonine kinase); FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1
products gene name :
MTOR
other gene names :
MTOR; MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mTOR
uniprot entry name :
MTOR_HUMAN
reactivity :
Human, Mouse
specificity :
15 amino acid peptide from near the amino terminus of human TOR
purity :
Immunoaffinity Purified
form :
PBS, 0.02% sodium azide.
storage stability :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
tested application :
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
app notes :
ICC, IHC-P (5 ug/ml), WB (1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: A 15 amino acid peptide from near the amino terminus of human TOR.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: MTOR antibody was raised against a 15 amino acid peptide from near the amino terminus of human TOR. Antigen Modification: N-Terminus
products categories :
Family: Protein Kinase. Subfamily: PI3/PI4
products description :
The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. It was initially discovered as a kinase whose ability to stimulate T cell proliferation in response to IL-2 could be inhibited by the immunosuppressive drug rapamycin.
ncbi acc num :
NP_004949.1
ncbi gb acc num :
NM_004958.3
ncbi mol weight :
288,892 Da
ncbi pathways :
AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!BDNF Signaling Pathway 712093
ncbi summary :
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]