catalog number :
MBS241215
products full name :
Rabbit Polyclonal to Human WT1 / Wilms Tumor 1
products short name :
WT1 / Wilms Tumor 1
products name syn :
Anti-WT1 / Wilms Tumor 1 Antibody (C-Terminus) IHC-plus; WT1; GUD; EWS-WT1; Amino-terminal domain of EWS; WAGR; WIT-2; Wilms tumor protein; AWT1; Wilms tumor 1; WT33; NPHS4; Human WT1; Wilms Tumor 1
other names :
Wilms tumor protein isoform D; Wilms tumor protein; Wilms tumor protein; amino-terminal domain of EWS last three zinc fingers of the DNA-binding domain of WT1; Wilms tumor 1; WT33
other gene names :
WT1; WT1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1
uniprot entry name :
WT1_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Peptide from the C-terminus of human WT1
purity :
Affinity Purified
form :
PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
concentration :
0.2 mg/ml
storage stability :
+4 degree C, avoid freezing
tested application :
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
app notes :
IHC-P (10 ug/ml), IP, WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human WT1.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: WT1 / Wilms Tumor 1 antibody was raised against synthetic peptide from human WT1. Antigen Modification: C-Terminus
ncbi acc num :
NP_077744.3
ncbi gb acc num :
NM_024426.4
ncbi mol weight :
33,086 Da
ncbi pathways :
Integrated Pancreatic Cancer Pathway 711360!!Regulation Of Telomerase Pathway 137987!!Transcriptional Misregulation In Cancer Pathway 523016!!Transcriptional Misregulation In Cancer Pathway 522987
ncbi summary :
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010]