Rabbit Polyclonal to Human NOS3 / eNOS | MyBioSource MBS241182 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human NOS3 / eNOS

catalog :

MBS241182

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS241182

products type :

Antibody

products full name :

Rabbit Polyclonal to Human NOS3 / eNOS

products short name :

NOS3 / eNOS

products name syn :

Anti-NOS3 / eNOS Antibody (C-Terminus) IHC-plus; NOS3; Constitutive NOS; CNOS; Endothelial NOS; ECNOS; NOS type III; NOSIII; EC-NOS; ENOS; Nitric oxide synthase 3; Human NOS3; eNOS

other names :

nitric oxide synthase, endothelial isoform 1; Nitric oxide synthase, endothelial; nitric oxide synthase, endothelial; cNOS; EC-NOS; NOSIII; NOS type III; endothelial NOS; constitutive NOS; nitric oxide synthase 3 transcript variant eNOS-delta20; nitric oxide synthase 3 transcript variant eNOS-delta21; nitric oxide synthase 3 transcript variant eNOS-delta20-21; nitric oxide synthase 3 (endothelial cell); Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII

products gene name :

NOS3

products gene name syn :

eNOS

other gene names :

NOS3; NOS3; eNOS; ECNOS; cNOS; eNOS; NOSIII

uniprot entry name :

NOS3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1203

specificity :

Peptide from the C-terminus of human NOS3

purity :

Affinity Purified

form :

PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.

concentration :

0.2 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human NOS3 / ENOS.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: NOS3 / eNOS antibody was raised against synthetic peptide from human NOS3 / ENOS. Antigen Modification: C-Terminus

products description :

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

40254422

ncbi acc num :

NP_000594.2

ncbi gb acc num :

NM_000603.4

uniprot acc num :

P29474

ncbi mol weight :

67,876 Da

ncbi pathways :

ACE Inhibitor Pathway (198763); AGE/RAGE Pathway (698754); Angiogenesis Pathway (198772); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Corticotropin-releasing Hormone Pathway (920957); Disease Pathway (530764)

ncbi summary :

uniprot summary :

eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. Protein type: EC 1.14.13.39; Oxidoreductase; Amino Acid Metabolism - arginine and proline. Chromosomal Location of Human Ortholog: 7q36. Cellular Component: Golgi membrane; cytoskeleton; cytoplasm; plasma membrane; caveola; nucleus; cytosol. Molecular Function: actin monomer binding; calmodulin binding; protein binding; FAD binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; FMN binding; iron ion binding; heme binding; NADP binding; cadmium ion binding. Biological Process: regulation of systemic arterial blood pressure by endothelin; negative regulation of potassium ion transport; negative regulation of muscle hyperplasia; positive regulation of vasodilation; nitric oxide metabolic process; negative regulation of cell proliferation; regulation of blood pressure; regulation of the force of heart contraction by chemical signal; negative regulation of hydrolase activity; lipopolysaccharide-mediated signaling pathway; negative regulation of blood pressure; angiogenesis; regulation of blood vessel size; nitric oxide biosynthetic process; interaction with host; mitochondrion organization and biogenesis; negative regulation of calcium ion transport; in utero embryonic development; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; ovulation from ovarian follicle; positive regulation of angiogenesis; response to heat; arginine catabolic process; endothelial cell migration; blood vessel remodeling; regulation of nitric-oxide synthase activity; blood coagulation; vascular endothelial growth factor receptor signaling pathway; nitric oxide mediated signal transduction; lung development; smooth muscle hyperplasia. Disease: Preeclampsia/eclampsia 1; Alzheimer Disease; Hypertension, Essential; Stroke, Ischemic

size1 :

0.05 mg

price1 :

495 USD