Rabbit Polyclonal to Human MMP7 | MyBioSource MBS241179 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human MMP7

catalog :

MBS241179

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241179

products type :

Antibody

products full name :

Rabbit Polyclonal to Human MMP7

products short name :

MMP7

products name syn :

Anti-MMP7 Antibody (C-Terminus) IHC-plus; MMP7; Matrilysin; Matrin; MMP-7; MPSL1; PUMP-1; Pump-1 protease; MPMM; Uterine matrilysin; Punctuated metalloproteinase 1; Matrix metalloproteinase-7; PUMP1; Uterine metalloproteinase; Human MMP7

other names :

matrilysin preproprotein; Matrilysin; matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine); matrix metallopeptidase 7 (matrilysin, uterine); Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase

products gene name :

MMP7

other gene names :

MMP7; MMP7; MMP-7; MPSL1; PUMP-1; MPSL1; PUMP1; MMP-7

uniprot entry name :

MMP7_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

267

specificity :

Peptide from the C-terminus of human MMP7

purity :

Immunoaffinity Purified

form :

PBS, pH 7.4, 0.1% BSA, 0.05% sodium azide.

concentration :

0.2 mg/ml

storage stability :

Store at 2-8 degree C for up to 1 year. Avoid repeated freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

app notes :

IHC-P (10 ug/ml), IP (2 - 5 ng/10E6 cells), WB (0.5 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS241179 was determined to be 10 ug/ml.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human MMP7.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MMP7 antibody was raised against synthetic peptide from human MMP7. Antigen Modification: C-Terminus

products categories :

Family: Protease. Subfamily: Metallopeptidase M10A

products description :

MMP7 is a Metallopeptidase M10A type protease. MMP-7 (Matrilysin) is constitutively produced by exocrine epithelial cells through out the body. It is capable of degrading casein, fibronectin, gelatins of types 1, III, IV, and V, in addition to activating procollagenase. It has been shown to play a key role in invasion by carcinomas.

ncbi gi num :

4505219

ncbi acc num :

NP_002414.1

ncbi gb acc num :

NM_002423.3

uniprot acc num :

P09237

ncbi mol weight :

29,677 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Alpha6-Beta4 Integrin Signaling Pathway (198807); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900); Syndecan-1-mediated Signaling Events Pathway (138046)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

uniprot summary :

MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family. Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.24.23. Chromosomal Location of Human Ortholog: 11q22.2. Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region. Molecular Function: zinc ion binding; metalloendopeptidase activity. Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; defense response to Gram-positive bacterium; extracellular matrix organization and biogenesis; antibacterial peptide biosynthetic process; proteolysis; defense response to Gram-negative bacterium; antibacterial peptide secretion; regulation of cell proliferation

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage