Rabbit Polyclonal to Human THPO / TPO / Thrombopoietin | MyBioSource MBS241093 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human THPO / TPO / Thrombopoietin

catalog :

MBS241093

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241093

products type :

Antibody

products full name :

Rabbit Polyclonal to Human THPO / TPO / Thrombopoietin

products short name :

THPO / TPO / Thrombopoietin

products name syn :

Anti-THPO / TPO / Thrombopoietin Antibody (aa35-50) IHC-plus; THPO; C-mpl ligand; MGDF; MPL ligand; THCYT1; Thrombopoietin nirs variant 1; MKCSF; MPLLG; Thrombopoietin; TPO; Human THPO; TPO; Thrombopoietin

other names :

thrombopoietin isoform 1; Thrombopoietin; thrombopoietin; MPL ligand; c-mpl ligand; prepro-thrombopoietin; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand; thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand

products gene name :

THPO

other gene names :

THPO; THPO; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1; MGDF; ML; MGDF

uniprot entry name :

TPO_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

353

specificity :

Amino acids 35 to 50 of human THPO

purity :

Protein G Purified

form :

PBS, 0.09% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA (1:000 - 1:1000), IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human THPO / Thrombopoietin.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: THPO / TPO / Thrombopoietin antibody was raised against synthetic peptide from human THPO / Thrombopoietin. Antigen Modification: aa35-50

products categories :

Family: Hormone

ncbi gi num :

4507493

ncbi acc num :

NP_000451.1

ncbi gb acc num :

NM_000460.3

uniprot acc num :

P40225

ncbi mol weight :

33,604 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (106028); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Platelet Aggregation (Plug Formation) Pathway (106053); Platelet Activation, Signaling And Aggregation Pathway (106034)

ncbi summary :

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]

uniprot summary :

THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Cytokine; Cell cycle regulation. Chromosomal Location of Human Ortholog: 3q27. Cellular Component: extracellular space. Molecular Function: growth factor activity; hormone activity; cytokine activity. Biological Process: cell proliferation; positive regulation of protein kinase B signaling cascade; platelet activation; multicellular organismal development; positive regulation of megakaryocyte differentiation; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; blood coagulation. Disease: Thrombocythemia 1

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage