Rabbit Polyclonal to Human DNMT / DNMT1 | MyBioSource MBS241017 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human DNMT / DNMT1

catalog :

MBS241017

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS241017

products type :

Antibody

products full name :

Rabbit Polyclonal to Human DNMT / DNMT1

products short name :

DNMT / DNMT1

products name syn :

Anti-DNMT / DNMT1 Antibody (aa1603-1616) IHC-plus; DNMT1; AIM; CXXC finger protein 9; CXXC9; DNA methyltransferase 1; DNMT; DNA methyltransferase HsaI; DNA MTase HsaI; HSN1E; M.HsaI; MCMT; Human DNMT; DNMT1

other names :

DNA (cytosine-5)-methyltransferase 1 isoform b; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; m.HsaI; DNA MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9; DNA (cytosine-5-)-methyltransferase 1; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMT

products gene name :

DNMT

products gene name syn :

DNMT1

other gene names :

DNMT1; DNMT1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; AIM; CXXC9; DNMT; Dnmt1; DNA MTase HsaI; M.HsaI

uniprot entry name :

DNMT1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

1616

specificity :

Amino acids 1603 to 1616 of human DNMT1

purity :

Protein G Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA (1:000 - 1:1000), IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human DNMT1.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: DNMT / DNMT1 antibody was raised against synthetic peptide from human DNMT1. Antigen Modification: aa1603-1616

products categories :

Family: C5-methyltransferase

products description :

ncbi gi num :

4503351

ncbi acc num :

NP_001370.1

ncbi gb acc num :

NM_001379.2

uniprot acc num :

P26358

ncbi mol weight :

144,465 Da

ncbi pathways :

Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); DNA Methylation Pathway (1127677); Epigenetic Regulation Of Gene Expression Pathway (1127671); Gene Expression Pathway (105937); Metabolic Pathways (132956); Methionine Degradation Pathway (413353); Methionine Degradation Pathway (468228); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

ncbi summary :

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

uniprot summary :

DNMT1: an ubiquitous DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development, and may play an active role in DNA damage repair. Mediates transcriptional repression by direct binding to HDAC2. Its abundance is reduced to non detectable levels at the G0 phase of the cell cycle and is dramatically induced upon entrance into the S-phase of the cell cycle. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Three isoforms of the human protein produced by alternative splicing have been described. Protein type: Methyltransferase, DNA; EC 2.1.1.37; Amino Acid Metabolism - cysteine and methionine; Transcription regulation; Methyltransferase; Cell development/differentiation. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: nucleoplasm; centric heterochromatin; replication fork; nucleus. Molecular Function: DNA (cytosine-5-)-methyltransferase activity; protein binding; DNA binding; methyl-CpG binding; zinc ion binding; RNA binding; chromatin binding; DNA-methyltransferase activity; transcription factor binding. Biological Process: negative regulation of histone H3-K9 methylation; maintenance of DNA methylation; transcription, DNA-dependent; gene silencing; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; regulation of gene expression, epigenetic; regulation of cell proliferation; negative regulation of gene expression, epigenetic; DNA methylation; gene expression; DNA methylation on cytosine. Disease: Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant; Neuropathy, Hereditary Sensory, Type Ie

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage