catalog number :
MBS241004
products full name :
Rabbit Polyclonal to Human BMP4
products short name :
BMP4
products name syn :
Anti-BMP4 Antibody (aa20-34) IHC-plus; BMP4; BMP-2B; BMP-4; BMP2B; BMP2B1; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; DVR4; MCOPS6; OFC11; Zyme; Human BMP4
other names :
bone morphogenetic protein 4 preproprotein; Bone morphogenetic protein 4; bone morphogenetic protein 4; BMP-4; BMP-2B; bone morphogenetic protein 2B; bone morphogenetic protein 4; Bone morphogenetic protein 2B; BMP-2B
products gene name :
BMP4
other gene names :
BMP4; BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP2B; DVR4; BMP-4; BMP-2B
uniprot entry name :
BMP4_HUMAN
specificity :
Amino acids 20 to 34 of human BMP4
purity :
Protein G Purified
form :
PBS, 0.09% sodium azide
storage stability :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
app notes :
ELISA (1:000 - 1:1000), IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human BMP4.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: BMP4 antibody was raised against synthetic peptide from human BMP4. Antigen Modification: aa20-34
products categories :
Family: TGF beta
products description :
Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Through molecular cloning, 7 BMP cDNAs, designated BMP1 through BMP7, have been recovered. BMP2 through BMP7, are members of the transforming growth factor-beta superfamily of regulatory molecules. Transcript variants utilizing alternative promoters and alternative non-coding first exons have been described in the literature.
ncbi acc num :
NP_001193.2
ncbi gb acc num :
NM_001202.3
ncbi mol weight :
46,555 Da
ncbi pathways :
Adipogenesis Pathway 198832!!BMP Signaling Pathway 1084755!!BMP Signaling Pathway 1108218!!Basal Cell Carcinoma Pathway 83113!!Basal Cell Carcinoma Pathway 525!!Cardiac Progenitor Differentiation Pathway 712094!!Elastic Fibre Formation Pathway 730310!!Extracellular Matrix Organization Pathway 576262!!Glypican 3 Network Pathway 138084!!Heart Development Pathway 198802
ncbi summary :
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]