Rabbit Polyclonal to Human MST1R / RON | MyBioSource MBS240876 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human MST1R / RON

catalog :

MBS240876

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS240876

products type :

Antibody

products full name :

Rabbit Polyclonal to Human MST1R / RON

products short name :

MST1R / RON

products name syn :

Anti-MST1R / RON Antibody (Internal) IHC-plus; MST1R; C-met-related tyrosine kinase; CD136; CDw136; CD136 antigen; Friend virus susceptibility 2; Fv2; MSP receptor; p185-Ron; PTK8 protein tyrosine kinase 8; RON; Soluble RON variant 3; Soluble RON variant 1; MST1R variant RON30; Oncogene RON; Human MST1R; RON

other names :

macrophage-stimulating protein receptor isoform 1 preproprotein; Macrophage-stimulating protein receptor; macrophage-stimulating protein receptor; p185-Ron; MSP receptor; RON variant 21; RON variant E2E3; MST1R variant RON30; MST1R variant RON62; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4; c-met-related tyrosine kinase; PTK8 protein tyrosine kinase 8; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); CDw136; Protein-tyrosine kinase 8; p185-Ron; CD_antigen: CD136Cleaved into the following 2 chains:Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain

products gene name :

MST1R

products gene name syn :

RON

other gene names :

MST1R; MST1R; RON; PTK8; CD136; CDw136; PTK8; RON; MSP receptor

uniprot entry name :

RON_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Bat, Gorilla, Human, Monkey. Predicted Reactivity: Gibbon, Bovine, Dog (at least 90% immunogen sequence identity)

sequence length :

1400

specificity :

Human MST1R / RON. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (2.4 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 18 amino acid peptide from internal region of human MST1R / RON. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Bat, Panda (100%); Gibbon, Dog, Bovine (94%); Hamster, Elephant (89%); Marmoset, Horse (83%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MST1R / RON antibody was raised against synthetic 18 amino acid peptide from internal region of human MST1R / RON. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Bat, Panda (100%); Gibbon, Dog, Bovine (94%); Hamster, Elephant (89%); Marmoset, Horse (83%). Antigen Modification: Internal

products categories :

Family: Protein Kinase. Subfamily: HGF Receptor/MET

products description :

MST1R/Ron, a HGF Receptor/MET -type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain.

ncbi gi num :

153946393

ncbi acc num :

NP_002438.2

ncbi gb acc num :

NM_002447.2

uniprot acc num :

Q04912

ncbi mol weight :

69,265 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway 198807!!A6b1 And A6b4 Integrin Signaling Pathway 138008!!Amb2 Integrin Signaling Pathway 137945

ncbi summary :

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]

size :

0.05 mg

price :

495 USD