Rabbit Polyclonal to Human GRM5 / MGLUR5 | MyBioSource MBS240873 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human GRM5 / MGLUR5

catalog :

MBS240873

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240873

products type :

Antibody

products full name :

Rabbit Polyclonal to Human GRM5 / MGLUR5

products short name :

GRM5 / MGLUR5

products name syn :

Anti-GRM5 / MGLUR5 Antibody (N-Terminus) IHC-plus; GRM5; GPRC1E; MGLUR5; Mglur5b; MGlu5; Human GRM5; MGLUR5

other names :

metabotropic glutamate receptor 5 isoform b; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5; protein phosphatase 1, regulatory subunit 86; glutamate receptor, metabotropic 5

products gene name :

GRM5

products gene name syn :

MGLUR5

other gene names :

GRM5; GRM5; mGlu5; GPRC1E; MGLUR5; PPP1R86; GPRC1E; MGLUR5; mGluR5

uniprot entry name :

GRM5_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Bat, Gibbon, Bovine, Chicken, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat. Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)

sequence length :

1180

specificity :

Human GRM5 / MGLUR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (5.6 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM5 / MGLUR5.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: GRM5 / MGLUR5 antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM5 / MGLUR5. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Hamster, Horse, Rabbit, Pig, Turkey, Zebra finch, Chicken, Platypus, Lizard (100%); Xenopus (94%); Opossum, Pufferfish (88%); Zebrafish (82%). Antigen Modification: N-Terminus

products categories :

Family: GPCR. Subfamily: Metabotropic glutamate

products description :

Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.

ncbi gi num :

4504143

ncbi acc num :

NP_000833.1

ncbi gb acc num :

NM_000842.4

uniprot acc num :

P41594

ncbi mol weight :

105,432 Da

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway (198839); Gap Junction Pathway (83072)

ncbi summary :

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

uniprot summary :

mGluR5: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 3. Chromosomal Location of Human Ortholog: 11q14.3. Cellular Component: integral to plasma membrane; postsynaptic density; cytoplasm; dendritic spine; plasma membrane; dendritic shaft. Molecular Function: G-protein coupled receptor activity; glutamate receptor activity; A2A adenosine receptor binding. Biological Process: synaptic transmission; desensitization of G-protein coupled receptor protein signaling pathway; regulation of synaptic transmission, glutamatergic; negative regulation of locomotion; regulation of transcription, DNA-dependent; metabotropic glutamate receptor, phospholipase C activating pathway; metabotropic glutamate receptor signaling pathway; protein kinase C activation; activation of MAPKKK activity; locomotory behavior; learning; cognition; positive regulation of long-term neuronal synaptic plasticity; protein amino acid phosphorylation

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage