antibody

Rabbit Polyclonal (IgG) to Human RGS2

MBS240845

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal (IgG) to Human RGS2

RGS2

Anti-RGS2 Antibody (aa1-50) IHC-plus; RGS2; G0S8; Human RGS2

regulator of G-protein signaling 2; Regulator of G-protein signaling 2; regulator of G-protein signaling 2; G0/G1 switch regulatory protein 8; cell growth-inhibiting protein 31; G0 to G1 switch regulatory 8, 24kD; cell growth-inhibiting gene 31 protein; regulator of G-protein signaling 2, 24kDa; regulator of G-protein signaling 2; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8

RGS2

RGS2; RGS2; G0S8; G0S8; RGS2

RGS2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

211

A synthetic peptide within amino acid residues 1-50 of human RGS2 was used as immunogen.

Protein G Purified

PBS, 0.2% gelatin, 0.05% sodium azide.

0.5 mg/ml

Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (20 ug/ml), WB (1 - 3 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Synthetic peptide from human RGS2.

Immunogen Type: Synthetic peptide. Immunogen: RGS2 antibody was raised against synthetic peptide from human RGS2. Antigen Modification: aa1-50

Family: Regulator of G-protein signalling

4506517

NP_002914.1

NM_002923.3

P41220

20,780 Da

Calcium Regulation In The Cardiac Cell Pathway (198906); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Myometrial Relaxation And Contraction Pathways (198759); Oxytocin Signaling Pathway (952859); Oxytocin Signaling Pathway (960764); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356); CGMP-PKG Signaling Pathway (983748)

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation. Protein type: Nucleolus; GAPs; GAPs, misc. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: internal side of plasma membrane; neuron projection; mitochondrion; cytoplasm; nucleolus; plasma membrane; cytosol. Molecular Function: calmodulin binding; protein binding; beta-tubulin binding; GTPase activator activity. Biological Process: regulation of translation; negative regulation of MAP kinase activity; relaxation of vascular smooth muscle; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of microtubule polymerization; brown fat cell differentiation; spermatogenesis; cell cycle; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

0.05 mg

495 USD